67619-86-7

Upstream product

• 1713-85-5 3-chloro-2-hydroxypropanoic acid 
• 108-95-2 phenol 
• 138250-73-4 2-chloro-3-hydroxypropionic acid 
• 139-02-6 sodium phenoxide 
• 141921-00-8 2-Acetoxy-2-phenoxymethyl-malonic acid diethyl ester 
• 6707-01-3 (chloromethoxy)benzene 
• 141921-17-7 2-Hydroxy-2-phenoxymethyl-malonic acid 

Downstream Products

• 141-76-4 3-iodopropanoic acid 
• 108-95-2 phenol 
• 141921-53-1 3-(Phenyloxy)lactic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of enantiomerically pure 3-aryloxy-2-hydroxypropanoic acids, intermediate products in the synthesis of cis-4-Aminochroman-3-ols

Oxidation of accessible (R)-3-chloropropane-1,2-diol to (R)-3-chloro-2-hydroxypropanoic acid and subsequent reaction of the latter with ortho-substituted sodium phenoxide gave a number of enantiomerically pure 3-aryloxy-2-hydroxypropanoic acid which are intermediate products in the synthesis of nonracemic 4-aminochroman-3-ols.

Enantioselective preparation of 2-alkyl-3-aryloxypropionic acids and esters and 3-alkyl-4-chromanones

Lipases provided access to chiral 2-alkyl-3-aryloxypropionic acids that gave chiral 3-alkyl-4-chromanones with high enantioselectivity.