67632-03-5

Upstream product

• 32864-11-2 2-Chloro-3,4-dihydroxybenzaldehyde 
• 5417-17-4 2-chloro-3,4-dimethoxybenzaldehyde 
• 37687-59-5 3,4-dibenzyloxy-2-chlorobenzaldehyde 

Downstream Products

• 67632-02-4 3,4-bis(benzyloxy)-2-chlorobenzoyl chloride 
• 1225208-84-3 C₂₇H₂₉ClN₂O₃ 

Relevant academic research and scientific papers

Preparation method of cephalosporin side chain

The invention provides a preparation method of a cephalosporin side chain. The method comprises the following steps of 2 - chlorine -3 and 4 -methoxybenzaldehyde as raw materials; and under the catalysis of a Lewis acid or base, 2 - chlorine -3 and 4 -dihydroxybenzaldehyde are removed. The hydroxyl group is then protected. Alkylation of aldehyde groups followed by amidation with 1 - (2 - aminoethyl) pyrrolidine gives 3 -position side chains of the cephalosporin. The method uses a novel starting material, is subjected to demethylation, protecting hydroxyl group, oxidizing aldehyde group and amidation to form a four-step reaction. The method is environmentally friendly, easily available in raw materials, simple and convenient to operate, high in product yield and purity, low in cost and easy for industrial production.