676324-77-9

Upstream product

• 676324-76-8 (3S,5S)-5-(4-methoxybenzyloxy)-3,6,6-trimethylheptan-1-ol 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 2746-25-0 p-Methoxybenzyl bromide 
• 67760-86-5 (3S)-2,2-dimethyl-5-hexen-3-ol 
• 197454-20-9 (S)-5,5-dimethyl-4-hydroxyhexan-2-one 
• 878626-76-7 acetic acid 1-[2-(4-methoxy-benzyloxy)-3,3-dimethyl-butyl]-1-methyl-allyl ester 
• 878626-77-8 (E)-(S)-5-(4-methoxybenzyloxy)-3,6,6-trimethyl-2-hepten-1-ol 
• 878626-87-0 (S)-5,5-dimethyl-4-(4-methoxybenzyloxy)-2-hexanone 
• 612492-41-8 (S)-tert-butyl (1-tert-butylbut-3-enyloxy)dimethylsilane 
• 612492-55-4 (S)-5,5-dimethyl-4-(tert-butyldimethylsilyloxy)hexan-2-one 
• 630-19-3 pivalaldehyde 
• 676324-75-7 (4S)-3-[(3R,5S)-5-(4-methoxybenzyloxy)-3,6,6-trimethylheptanoyl]-4-phenyloxazolidin-2-one 
• 676324-74-6 (4S)-3-[(5S)-5-(4-methoxybenzyloxy)-6,6-dimethylhept-2-enoyl]-4-phenyloxazolidin-2-one 
• 676324-73-5 (3S)-3-(para-methoxybenzyloxy)-4,4-dimethylpentanal 

Downstream Products

• 676324-80-4 (3R,4S,6S,8S)-8-(4-methoxybenzyloxy)-3,6,9,9-tetramethyldec-1-en-4-ol 
• 1585181-02-7 (4S,6S,8S)-8-(4-methoxybenzyloxy)-6,9,9-tetramethyldec-1-en-4-ol 
• 1333536-80-3 C₆₂H₈₅N₅O₁₁S 
• 1585181-30-1 pyrrolidine-1,2-dicarboxylic acid (2S)-2-{(1S,3S,5S)-6-[(1S)-3-allyloxycarbonyl-1-[(triphenylmethylthio)methyl]propylcarbamoyl]-1-tert-butyl-3-methyl-5-(2,2,2-trichloroethoxycarbonyloxy)hex-1-yl}ester 1-(9H-fluoren-9-ylmethyl)ester 
• 1585180-89-7 pyrrolidine-1,2-dicarboxylic acid (2S)-2-{(1S,3S,5S)-6-[(1S)-3-allyloxycarbonyl-1-[(triphenylmethylthio)methyl]propylcarbamoyl]-1-tert-butyl-5-hydroxy-3-methylhex-1-yl}ester 1-(9H-fluoren-9-ylmethyl)ester 
• 1585180-71-7 methyl (3S,5S,7S)-3-hydroxy-7-(4-methoxybenzyloxy)-2,2,5,8,8-pentamethylnonanoate 
• 1177263-68-1 (3S,4S,6S,8S)-8-(4-methoxybenzyloxy)-3,6,9,9-tetramethyldec-1-en-4-ol 
• 1177263-69-2 (3R,4R,6S,8S)-8-(4-methoxybenzyloxy)-3,6,9,9-tetramethyldec-1-en-4-ol 
• 676324-81-5 (3R,4S,6S,8S)-8-(4-methoxybenzyloxy)-3,6,9,9-tetramethyl-4-(tert-butyldimethylsilanyloxy)dec-1-ene 
• 582321-75-3 pyrrolidine-1,2-dicarboxylic acid (2S)-2-[(1S,3S,5S,6S,8R)-8-benzoyloxy-1-tert-butyl-5-(tert-butyldimethylsilyloxy)-3,6-dimethyl-7-oxononyl] ester 1-tert-butyl ester 
• 350791-64-9 (-)-apratoxin A 
• 878626-85-8 1-[(9H-fluoren-9-yl)methyl] 2-[(3S,5S,7S,8S)-8-({S}-4-{[5S,8S,11S,E]-11-[(S)-sec-butyl]-5-[4-methoxybenzyl]-2,7,8,10-tetramethyl-3,6,9,12-tetraoxo-13-oxa-4,7,10-triazahexadeca-1,15-dien-1-yl}-4,5-dihydrothiazol-2-yl)-7-hydroxy-2,2,5-trimethylnonan-3-yl] (S)-pyrrolidine-1,2-dicarboxylate 
• 878626-72-3 1-[(9H-fluoren-9-yl)methyl] 2-[(3S,5S,7S,8S)-9-{[(S,E)-5-(allyloxy)-4-methyl-5-oxo-1-(tritylthio)pent-3-en-2-yl]amino}-2,2,5,8-tetramethyl-9-oxo-7-{[(2,2,2-trichloroethoxy)carbonyl]oxy}nonan-3-yl] (S)-pyrrolidine-1,2-dicarboxylate 
• 878626-89-2 (S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(1S,3S,5S,6S)-6-((E)-(S)-3-allyloxycarbonyl-1-tritylsulfanylmethyl-but-2-enylcarbamoyl)-1-tert-butyl-5-hydroxy-3-methyl-heptyl] ester 1-(9H-fluoren-9-ylmethyl) ester 

Relevant academic research and scientific papers

MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT

The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders.

Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity

Apratoxins are cytotoxic natural products originally isolated from marine cyanobacteria that act by preventing cotranslational translocation early in the secretory pathway to downregulate receptor levels and inhibit growth factor secretion, leading to pot

Total synthesis of (-)-apratoxin A, 34-epimer, and its oxazoline analogue

A concise and convergent total synthesis of the highly cytotoxic marine natural product apratoxin A is accomplished by an 18-step linear sequence. The high sensitivity of the thiazoline, bearing an adjacent β-hydroxyl group at the C35-position, results in

Total synthesis of apratoxin A

We have achieved a total synthesis of apratoxin A in which thiazoline formation was accomplished from the moCys containing amide 4 using PPh 3(O)/Tf2O. Deprotection of the Troc and allyl ester in 17, coupling with tripeptide 3, and d

Synthesis of the polyketide segment of apratoxin A

Apratoxin A 1 is a potent cytotoxic agent extracted from a marine cyanobacterium. We report the results of our synthetic approaches to the polyketide segment 3-OTBS-7-OPMB-2,5,8,8-tetramethylnonanoic acid 4, and the scope and limitations of these approach