676324-77-9Relevant articles and documents
MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT
-
, (2015/09/28)
The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders.
Total synthesis of (-)-apratoxin A, 34-epimer, and its oxazoline analogue
Numajiri, Yoshitaka,Takahashi, Takashi,Doi, Takayuki
scheme or table, p. 111 - 125 (2010/07/06)
A concise and convergent total synthesis of the highly cytotoxic marine natural product apratoxin A is accomplished by an 18-step linear sequence. The high sensitivity of the thiazoline, bearing an adjacent β-hydroxyl group at the C35-position, results in
Synthesis of the polyketide segment of apratoxin A
Xu, Zhengshuang,Chen, Zhiyong,Ye, Tao
, p. 355 - 363 (2007/10/03)
Apratoxin A 1 is a potent cytotoxic agent extracted from a marine cyanobacterium. We report the results of our synthetic approaches to the polyketide segment 3-OTBS-7-OPMB-2,5,8,8-tetramethylnonanoic acid 4, and the scope and limitations of these approach