676324-78-0Relevant articles and documents
MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT
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, (2015/09/28)
The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders.
Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity
Chen, Qi-Yin,Liu, Yanxia,Cai, Weijing,Luesch, Hendrik
, p. 3011 - 3029 (2014/05/06)
Apratoxins are cytotoxic natural products originally isolated from marine cyanobacteria that act by preventing cotranslational translocation early in the secretory pathway to downregulate receptor levels and inhibit growth factor secretion, leading to pot
Synthesis of the polyketide segment of apratoxin A
Xu, Zhengshuang,Chen, Zhiyong,Ye, Tao
, p. 355 - 363 (2007/10/03)
Apratoxin A 1 is a potent cytotoxic agent extracted from a marine cyanobacterium. We report the results of our synthetic approaches to the polyketide segment 3-OTBS-7-OPMB-2,5,8,8-tetramethylnonanoic acid 4, and the scope and limitations of these approach