676449-15-3Relevant articles and documents
Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways
Rosser, Edward M.,Morton, Simon,Ashton, Kate S.,Cohen, Philip,Hulme, Alison N.
, p. 142 - 149 (2007/10/03)
The synthesis of C(4)H and C(4)Me analogues of the JNK/p38 pathway activator anisomycin, based upon an aldol or Claisen construction of the C(3)-C(4) bond, has been demonstrated. The relative activation of the JNK/SAPK1 and p38/SAPK2 pathways in RAW macrophages by these analogues, and their synthetic precursors, has been assessed using immunoblot assays against phosphorylated c-Jun and MAPKAP-K2. These studies demonstrate that some of the synthetic C(4) analogues are also potent activators of these stress kinase pathways.