676457-74-2

Upstream product

• 73058-30-7 (2S)-2-benzylazacyclopropane 
• 507-09-5 tiolacetic acid 
• 122818-32-0 (S)-2-<(tert-Butoxycarbonyl)amino>-3-phenylpropyl thioacetate 
• 676457-72-0 (S)-2-(acetylamino)-3-phenylpropyl thioacetate 

Downstream Products

• 943866-23-7 (S)-2-acetylamino-3-phenylpropane-1-sulfonic acid 
• 126301-32-4 (S)-2-amino-3-phenylpropane-1-sulfonic acid 

Relevant academic research and scientific papers

Efficient synthesis of taurine and structurally diverse substituted taurines from aziridines

(Chemical Equation Presented) Taurine and substituted taurines were synthesized efficiently from aziridines via ring-opening reaction with thioacetic acid, oxidation with performic acid, and hydrolysis in hydrochloric acid. The current method shows more benefit in purification and efficiency in the preparation of taurine and structurally diverse 2-substituted, 2,2-disubstituted, and 1,2-, 2,2-, and 2,N-alkylene taurines.

Inhibition of α-chymotrypsin with thiol-bearing substrate analogues in the presence of zinc ion

We have demonstrated that thiol-bearing analogues of α-chymotrysin (α-CT) substrates such as (S)-(1-benzyl-2-thiolethyl)-carbamic acid, benzyl ester (3) inhibits α-CT, a prototypical serine protease, in the presence of Zn(II) ion. They constitute a novel class of small molecule inhibitors for α-CT believed to inhibit the enzyme by forming a ternary complex consisting of α-CT, Zn(II) ion, and the inhibitor.