67646-68-8

Upstream product

• 2550-26-7 4-Phenyl-2-butanone 
• 4301-14-8 acetylenemagnesium bromide 
• 74-86-2 acetylene 
• 1066-54-2 trimethylsilylacetylene 
• 75-20-7 calcium carbide 
• 1449379-52-5 C₁₅H₂₂OSi 
• 1777-03-3 2-triethylsilylacetylene 
• 74866-72-1 3-Methyl-5-phenyl-2-phenylselanyl-pent-1-en-3-ol 
• 65032-27-1 ethynylmagnesium chloride 
• 925-90-6 ethylmagnesium bromide 

Downstream Products

• 70600-62-3 3-methyl-5-phenyl-pent-3-en-1-yne 
• 64633-20-1 (E)-4-methyl-5-phenylpent-3-en-2-one 
• 107647-42-7 trans-3-Methyl-5-phenyl-2-pentenal 
• 159028-45-2 3-methyl-5-phenylpent-1-yn-3-yl acetate 
• 632291-67-9 4-methyl-5-methylidene-4-phenethyl-1,3-dioxolan-2-one 
• 1082207-57-5 C₁₄H₁₆O₃ 
• 1449379-54-7 C₁₈H₁₇N₃O 
• 1449379-55-8 1-(2-azidophenyl)-3-methyl-5-phenylpent-1-yn-3-yl acetate 
• 1449379-98-9 C₂₀H₁₉NO₂ 
• 1449379-53-6 C₁₈H₁₉NO 
• 1500099-00-2 C₁₃H₁₅NO₂ 
• 83542-41-0 (E)-3-methyl-5-phenyl-4-pentene-2-one 
• 83520-80-3 (E)-3-methyl-5-phenylpent-3-en-2-one 
• 110211-32-0 (3-methylnona-3,4-dienyl)benzene 

Relevant academic research and scientific papers

Ligand-Controlled Palladium-Catalyzed Carbonylation of Alkynols: Highly Selective Synthesis of α-Methylene-β-Lactones

The first general and regioselective Pd-catalyzed cyclocarbonylation to give α-methylene-β-lactones is reported. Key to the success for this process is the use of a specific sterically demanding phosphine ligand based on N-arylated imidazole (L11) in the presence of Pd(MeCN)2Cl2 as pre-catalyst. A variety of easily available alkynols provide under additive-free conditions the corresponding α-methylene-β-lactones in moderate to good yields with excellent regio- and diastereoselectivity. The applicability of this novel methodology is showcased by the direct carbonylation of biologically active molecules including natural products.

THERAPEUTIC COMPOUNDS AND USES THEREOF

The present invention relates to compounds of formula (I): and to salts thereof, wherein R1-R6 have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of TAF1. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various TAF1-mediated disorders.

Catalytic Nucleophilic Fluorination of Secondary and Tertiary Propargylic Electrophiles with a Copper-N-Heterocyclic Carbene Complex

A catalytic method for the nucleophilic fluorination of propargylic electrophiles is described. Our protocol involves the use of a Cu(NHC) complex as the catalyst and is suitable for the preparation of secondary and tertiary propargylic fluorides without

Facile Alder-Ene Reactions of Silylallenes Involving an Allenic C(sp2)-H Bond

Facile and selective Alder-ene reactions of silylallenes involving the activation of an allenic C(sp2)-H over an allylic C(sp3)-H bond is described. In this ene reaction, the presence of a silyl substituent was found to be critical for the observed reactivity and selectivity since the corresponding alkyl-substituted allenes show different reaction profiles. Computational studies show that the origin of this unusual reactivity is the lower bond dissociation energy of the α-C(sp2)-H bond in silylallenes compared to the corresponding nonsilylated allenes.

Synthesis of acetylenic alcohols with calcium carbide as the acetylene source

Propargyl alcohols containing a terminal alkyne group are highly important and versatile intermediates. Here, we report the synthesis of these compounds from an inexpensive and renewable resource, calcium carbide (CaC2). No metal catalysts are required in this new protocol and the reactions take place under very mild conditions.

Au-catalyzed formation of functionalized quinolines from 2-alkynyl arylazide derivatives

A new method for converting 2-alkynyl arylazide derivatives into functionalized polysubstituted quinolines following a gold-catalyzed 1,3-acetoxy shift/cyclization/1,2-group shift sequence has been developed. This transformation proceeds under mild reaction conditions, is efficient, and tolerates a large variety of functional groups.

Mild conversion of propargylic alcohols to α,β-unsaturated enones in ionic liquids (ILs); A new 'metal free' life for the Rupe rearrangement

A mild and selective transition metal free protocol for the conversion of propargylic alcohols to cyclic and acyclic α,β-unsaturated enones via the Rupe rearrangement is reported. The method utilizes the Br?nsted acidic ionic liquid [BMIM-SO3H][OTf] as catalyst and [BMIM][PF 6] as solvent and offers the potential for recycling and reuse of the IL solvent. The feasibility to synthesize bicyclic fused cyclopentenone derivatives via a Rupe → Aldol → Nazarov sequence utilizing this protocol has also been demonstrated.

Mo-Au combo catalysis for rapid 1,3-rearrangement of propargyl alcohols into α,ss-unsaturated carbonyl compounds

The combination of Mo and cationic Au catalysts dramatically accelerated the rearrangement of diverse propargyl alcohols, which includes a short reaction time, mild conditions, and high product yields. A practical application to the highly challenging primary propargyl alcohols and the N-alkynyl amides is achieved.

Hydrocarboxylation of allenes with CO2 catalyzed by silyl pincer-type palladium complex

Tridentate PSiP pincer-type palladium complex-catalyzed hydrocarboxylation of allenes under carbon dioxide to give synthetically useful β,γ-unsaturated carboxylic acids was developed. This novel CO2-fixation reaction is thought to proceed through the catalytic generation of σ-allyl palladium species via hydropalladation of allenes, followed by its regioselective nucleophilic addition to CO2 in the presence of an appropriate reducing agent. The reaction is successfully applied to various allenes bearing functional groups such as ester, carbamate, ketone, and alkene, showing high synthetic utility of this protocol. Copyright

Synthesis and inhibitory activity of 4-alkynyl and 4-alkenylquinazolines: Identification of new scaffolds for potent EGFR tyrosine kinase inhibitors

The present study identified several 4-alkynyl and 4-alkenylquinazolines that serve as novel and potent EGFR tyrosine kinase inhibitors. The IC50 values of these compounds are in the nanomolar range. In addition, the 4-(4-phenylbut-1-yn/en-yl)q