676485-93-1Relevant academic research and scientific papers
Bridged peptide macrocycles as ligands for PDZ domain proteins
Udugamasooriya, Gomika,Saro, Dorina,Spaller, Mark R.
, p. 1203 - 1206 (2005)
(Chemical Equation Presented) Conformationally constrained side chain-bridged cyclic peptides were prepared using bis-carboxylic acid ring spacers. These macrocyles were designed to inhibit protein-protein interactions mediated by the third PDZ domain (PDZ3) of a mammalian neuronal protein, PSD-95. Isothermal titration calorimetry (ITC) experiments measured dissociation constants in the low micromolar range. For each compound, the change in entropy (TΔS) of binding either is comparable in magnitude to the enthalpy change (ΔH) or is the predominant driving force for association.
PEPTIDE CONJUGATES AND METHODS OF USE
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Paragraph 0427, (2021/06/11)
Peptide conjugates comprising a peptide selected from a peptide that modulates the PYY receptor, a peptide that modulates both the GLP-1 receptor and the GCG receptor, a peptide that modulates both the GLP-1 receptor and the GIP receptor, and a peptide that modulates the GLP-1 receptor; and a staple attached to the peptide at a first amino acid and a second amino acid are disclosed herein. Also provided are peptide conjugates comprising prolactin-releasing peptide. The peptide conjugates may be used for treating conditions such as obesity. Further provided are stapled prolactin-releasing peptide.
