676487-49-3

Upstream product

• 91133-59-4 3-methyl-3-phenyl-2-oxobutanoic acid 
• 74-89-5 methylamine 
• 676487-31-3 3-methyl-2-(methylamino)-3-phenylbutanenitrile 

Downstream Products

• 676635-56-6 C₂₉H₄₇N₃O₄ 

Relevant academic research and scientific papers

Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies

The stereochemistry of the tubulin inhibitors taltobulin HTI-286 (2) and HTI-042 (3) was determined by utilizing the DPFGSE 1D NOE experiment. Single crystal X-ray diffraction analysis further confirmed the absolute configuration of these two compounds, w

Process for the synthesis of intermediates useful for the synthesis of tubulin inhibitors

The invention is a process for the preparation of compounds of the Formula I: where R1, R2, R3, R4 and R5 are defined in the specification, which are intermediates useful for the preparation of tubulin inhibitors which are useful in the treatment of cancer.