676494-58-9

Basic information

• Product Name: Benzonitrile, 3-chloro-4-(4-formylphenoxy)-
• CAS NO: 676494-58-9
• Molecular Formula: C14H8ClNO2
• Molecular Weight: 257.676
• Mol File: 676494-58-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 3-chloro-4-(4-formylphenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 3-chloro-4-(4-formylphenoxy)-(676494-58-9)
• EPA Substance Registry System: Benzonitrile, 3-chloro-4-(4-formylphenoxy)-(676494-58-9)

Safety Data

• Hazardous Substances Data: 676494-58-9(Hazardous Substances Data)

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 117482-84-5 3-chloro-4-fluorobenzonitrile 

Downstream Products

• 676494-59-0 3-chloro-4-(4-formylphenoxy)benzamide 
• 1346133-07-0 3-chloro-4-[4-[ [2-(3-pyridyl)pyrrolidin-1-yl]methyl]phenoxy]benzamide 
• 1346133-08-1 3-chloro-4-[4-[ [ (2S)-2-(3-pyridyl)pyrrolidin-1-yl]methyl]phenoxy]benzamide 
• 1346133-09-2 3-chloro-4-[4-[ [ (2R)-2-(3-pyridyl)pyrrolidin-1-yl]methyl]phenoxy]benzamide 

Relevant articles and documents

Discovery of aminobenzyloxyarylamides as κ opioid receptor selective antagonists: Application to preclinical development of a κ opioid receptor antagonist receptor occupancy tracer

Arylphenylpyrrolidinylmethylphenoxybenzamides were found to have high affinity and selectivity for κ opioid receptors. On the basis of receptor binding assays in Chinese hamster ovary (CHO) cells expressing cloned human opioid receptors, (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl) phenoxy)benzamide (25) had a Ki = 0.565 nM for κ opioid receptor binding while having a Ki = 35.8 nM for μ opioid receptors and a Ki = 211 nM for δ opioid receptor binding. Compound 25 was also a potent antagonist of κ opioid receptors when tested in vitro using a [35S]-guanosine 5′O-[3-thiotriphosphate] ([35S]GTP-γ-S) functional assay in CHO cells expressing cloned human opioid receptors. Compounds were also evaluated for potential use as receptor occupancy tracers. Tracer evaluation was done in vivo, using liquid chromatography-tandem mass spectrometry (LC/MS/MS) methods, precluding the need for radiolabeling. (S)-3-Chloro-4-(4-((2-(pyridine-3-yl)pyrrolidin-1-yl)methyl) phenoxy)benzamide (18) was found to have favorable properties for a tracer for receptor occupancy, including good specific versus nonspecific binding and good brain uptake.

DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONIST

A compound of the formula (I) wherein the variables X1 to X10, R1 to R7 including R3', E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.