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CAS

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1346133-08-1

LY-2795050, also known as BMS-262084, is a selective non-peptide antagonist for the melanin concentrating hormone receptor-1 (MCHR1). It is a chemical compound that has been studied for its potential applications in the treatment of obesity and related metabolic disorders. LY-2795050 has demonstrated its ability to regulate food intake and weight gain in animal models, offering a novel approach to controlling appetite and reducing excess body weight by blocking the MCHR1 receptor.

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  • 1346133-08-1 Structure

  • Basic information

    1. Product Name: LY-2795050
    2. Synonyms: 3-chloro-4-[4-[ [ (2S)-2-(3-pyridyl)pyrrolidin-1-yl]methyl]phenoxy]benzamide;LY 2795050;LY2795050;LY-2795050
    3. CAS NO:1346133-08-1
    4. Molecular Formula: C23H22ClN3O2
    5. Molecular Weight: 407.89268
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1346133-08-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 532.4±50.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.287±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 15.57±0.50(Predicted)
    10. CAS DataBase Reference: LY-2795050(CAS DataBase Reference)
    11. NIST Chemistry Reference: LY-2795050(1346133-08-1)
    12. EPA Substance Registry System: LY-2795050(1346133-08-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1346133-08-1(Hazardous Substances Data)

1346133-08-1 Usage

Uses

Used in Pharmaceutical Industry:
LY-2795050 is used as a potential therapeutic agent for the treatment of obesity and related metabolic disorders. Its application is based on its ability to regulate food intake and weight gain by blocking the MCHR1 receptor, which may help in controlling appetite and reducing excess body weight.
Used in Preclinical Research:
LY-2795050 is used as a research tool in preclinical studies to investigate its potential effects on appetite regulation and weight management. These studies aim to understand the compound's mechanism of action and its efficacy in animal models, providing valuable insights for further research and development.

Check Digit Verification of cas no

The CAS Registry Mumber 1346133-08-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,6,1,3 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1346133-08:
(9*1)+(8*3)+(7*4)+(6*6)+(5*1)+(4*3)+(3*3)+(2*0)+(1*8)=131
131 % 10 = 1
So 1346133-08-1 is a valid CAS Registry Number.

1346133-08-1Downstream Products

1346133-08-1Relevant articles and documents

Radiosynthesis of [11C]LY2795050 for Preclinical and Clinical PET Imaging Using Cu(II)-Mediated Cyanation

Yang, Lingyun,Brooks, Allen F.,Makaravage, Katarina J.,Zhang, Huibin,Sanford, Melanie S.,Scott, Peter J. H.,Shao, Xia

, p. 1274 - 1279 (2018)

Copper-mediated 11C-cyanation reactions have enabled the synthesis of PET radiotracers from a range of readily available precursors and avoid the need to use more toxic Pd catalysts. In this work we adapt our recently developed 11C-c

Discovery of aminobenzyloxyarylamides as κ opioid receptor selective antagonists: Application to preclinical development of a κ opioid receptor antagonist receptor occupancy tracer

Mitch, Charles H.,Quimby, Steven J.,Diaz, Nuria,Pedregal, Concepcion,De La Torre, Marta G.,Jimenez, Alma,Shi, Qing,Canada, Emily J.,Kahl, Steven D.,Statnick, Michael A.,McKinzie, David L.,Benesh, Dana R.,Rash, Karen S.,Barth, Vanessa N.

, p. 8000 - 8012 (2012/01/19)

Arylphenylpyrrolidinylmethylphenoxybenzamides were found to have high affinity and selectivity for κ opioid receptors. On the basis of receptor binding assays in Chinese hamster ovary (CHO) cells expressing cloned human opioid receptors, (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl) phenoxy)benzamide (25) had a Ki = 0.565 nM for κ opioid receptor binding while having a Ki = 35.8 nM for μ opioid receptors and a Ki = 211 nM for δ opioid receptor binding. Compound 25 was also a potent antagonist of κ opioid receptors when tested in vitro using a [35S]-guanosine 5′O-[3-thiotriphosphate] ([35S]GTP-γ-S) functional assay in CHO cells expressing cloned human opioid receptors. Compounds were also evaluated for potential use as receptor occupancy tracers. Tracer evaluation was done in vivo, using liquid chromatography-tandem mass spectrometry (LC/MS/MS) methods, precluding the need for radiolabeling. (S)-3-Chloro-4-(4-((2-(pyridine-3-yl)pyrrolidin-1-yl)methyl) phenoxy)benzamide (18) was found to have favorable properties for a tracer for receptor occupancy, including good specific versus nonspecific binding and good brain uptake.

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