676500-39-3

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Difluoro-4-hydroxybenzaldehyde is utilized as a key building block in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical sector, 2,3-Difluoro-4-hydroxybenzaldehyde serves as an essential intermediate for the production of agrochemicals, contributing to the creation of more effective and environmentally friendly pesticides and herbicides.
Used in Dye Industry:
2,3-Difluoro-4-hydroxybenzaldehyde is employed as a precursor in the synthesis of dyes, offering a wide range of color options and improved properties such as lightfastness and stability.
Used in Fragrance and Flavoring Industry:
2,3-Difluoro-4-hydroxybenzaldehyde is used as a starting material for the production of fragrances and flavoring agents, providing unique scents and tastes due to its distinct chemical structure.
Used in Material Science:
2,3-Difluoro-4-hydroxybenzaldehyde has potential applications in the development of new materials, such as polymers and coatings, with enhanced properties like durability, heat resistance, and chemical stability.
Used as a Research Tool in Organic Chemistry:
In the field of organic chemistry, 2,3-Difluoro-4-hydroxybenzaldehyde serves as a valuable research tool, enabling scientists to explore new reaction pathways and develop innovative synthetic methods.

InChI:InChI=1/C7H4F2O2/c8-6-4(3-10)1-2-5(11)7(6)9/h1-3,11H

Upstream product

• 256417-11-5 2,3-difluoro-4-methoxy-benzaldehyde 
• 1010800-88-0 2,3-difluoro-4-((triisopropylsilyl)oxy)benzoic acid 
• 6418-38-8 2,3-difluorophenol 
• 749230-30-6 (2,3-difluorophenoxy)triisopropylsilane 
• 1010801-00-9 2,3-difluoro-4-((triisopropylsilyl)oxy)benzaldehyde 

Downstream Products

• 256417-11-5 2,3-difluoro-4-methoxy-benzaldehyde 
• 1010801-01-0 methyl 3-(2,3-difluoro-4-methoxyphenyl)-3-hydroxy-2,2-dimethylpropanoate 
• 1010801-02-1 methyl 3-(2,3-difluoro-4-methoxyphenyl)-2,2-dimethyl-3-oxopropanoate 
• 1010801-04-3 3-(2,3-difluoro-4-hydroxyphenyl)-4,4-dimethyl-1H-pyrazol-5(4H)-one 
• 1010802-00-2 C₂₉H₂₉F₅N₆O₄ 
• 1093857-65-8 2-[4-[2,3-Difluoro-4-(4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-3-yl)phenoxy]butyl]-5-(8-methoxy-2-trifluoromethylimidazo[1,2-a]pyridin-5-yl)-4,4-dimethyl-2,4-dihydro-pyrazol-3-one 
• 1093857-58-9 2-[4-[2,3-difluoro-4-(4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-3-yl)phenoxy]butyl]-5-(4-methoxy-2-trifluoromethylbenzo[d]thiazol-7-yl)-4,4-dimethyl-2,4-dihydro-pyrazol-3-one 
• 1010801-03-2 5-(2,3-Difluoro-4-methoxyphenyl)-4,4-dimethyl-2,4-dihydropyrazol-3-one 
• 1617504-91-2 (Z)-5-(10-hydroxy-11,12-difluorobenzylidene)imidazolidine-2,4-dione 

Relevant academic research and scientific papers

Phosphodiesterase inhibitors. Part 5: Hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration

(-)-6-(7-Methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl) -5-methyl-4,5-dihydropyridazin-3(2H)-one (KCA-1490) exhibits moderate dual PDE3/4-inhibitory activity and promises as a combined bronchodilatory/anti- inflammatory agent. N-alkylation of the pyridazinone ring markedly enhances potency against PDE4 but suppresses PDE3 inhibition. Addition of a 6-aryl-4,5-dihydropyridazin-3(2H)-one extension to the N-alkyl group facilitates both enhancement of PDE4-inhibitory activity and restoration of potent PDE3 inhibition. Both dihydropyridazinone rings, in the core and extension, can be replaced by achiral 4,4-dimethylpyrazolone subunits and the core pyrazolopyridine by isosteric bicyclic heteroaromatics. In combination, these modifications afford potent dual PDE3/4 inhibitors that suppress histamine-induced bronchoconstriction in vivo and exhibit promising anti-inflammatory activity via intratracheal administration.

PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT

It is to provide a novel pyrazolone derivative represented by the following general formula (1), which is useful as a pharmaceutical and has a phosphodiesterase inhibitory action: wherein R1,R2: C1-6 alkyl; R3,R4: H, X, C1-6 alkoxy; Z:O, S; A:AA, BB, wherein AA represents wherein BB represents wherein R5: H, C1-6 alkyl ; R6,R7: C1-6 alkyl.

Halogenated analogs of 1′-acetoxychavicol acetate, Rev-export inhibitor from Alpinia galanga, designed from mechanism of action

In the course of search for the robust analogs of 1′-acetoxychavicol acetate (ACA, 1), the Rev-export inhibitor from the medicinal plant Alpinia galanga, we clarified formation of the quinone methide intermediate ii to be essential for exerting the inhibi