676500-39-3

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Difluoro-4-hydroxybenzaldehyde is utilized as a key building block in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical sector, 2,3-Difluoro-4-hydroxybenzaldehyde serves as an essential intermediate for the production of agrochemicals, contributing to the creation of more effective and environmentally friendly pesticides and herbicides.
Used in Dye Industry:
2,3-Difluoro-4-hydroxybenzaldehyde is employed as a precursor in the synthesis of dyes, offering a wide range of color options and improved properties such as lightfastness and stability.
Used in Fragrance and Flavoring Industry:
2,3-Difluoro-4-hydroxybenzaldehyde is used as a starting material for the production of fragrances and flavoring agents, providing unique scents and tastes due to its distinct chemical structure.
Used in Material Science:
2,3-Difluoro-4-hydroxybenzaldehyde has potential applications in the development of new materials, such as polymers and coatings, with enhanced properties like durability, heat resistance, and chemical stability.
Used as a Research Tool in Organic Chemistry:
In the field of organic chemistry, 2,3-Difluoro-4-hydroxybenzaldehyde serves as a valuable research tool, enabling scientists to explore new reaction pathways and develop innovative synthetic methods.

InChI:InChI=1/C7H4F2O2/c8-6-4(3-10)1-2-5(11)7(6)9/h1-3,11H

Upstream product

• 256417-11-5 2,3-difluoro-4-methoxy-benzaldehyde 
• 1010800-88-0 2,3-difluoro-4-((triisopropylsilyl)oxy)benzoic acid 
• 6418-38-8 2,3-difluorophenol 
• 749230-30-6 (2,3-difluorophenoxy)triisopropylsilane 
• 1010801-00-9 2,3-difluoro-4-((triisopropylsilyl)oxy)benzaldehyde 

Downstream Products

• 256417-11-5 2,3-difluoro-4-methoxy-benzaldehyde 
• 1010801-01-0 methyl 3-(2,3-difluoro-4-methoxyphenyl)-3-hydroxy-2,2-dimethylpropanoate 
• 1010801-02-1 methyl 3-(2,3-difluoro-4-methoxyphenyl)-2,2-dimethyl-3-oxopropanoate 
• 1010801-04-3 3-(2,3-difluoro-4-hydroxyphenyl)-4,4-dimethyl-1H-pyrazol-5(4H)-one 
• 1010802-00-2 C₂₉H₂₉F₅N₆O₄ 
• 1093857-65-8 2-[4-[2,3-Difluoro-4-(4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-3-yl)phenoxy]butyl]-5-(8-methoxy-2-trifluoromethylimidazo[1,2-a]pyridin-5-yl)-4,4-dimethyl-2,4-dihydro-pyrazol-3-one 
• 1093857-58-9 2-[4-[2,3-difluoro-4-(4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-3-yl)phenoxy]butyl]-5-(4-methoxy-2-trifluoromethylbenzo[d]thiazol-7-yl)-4,4-dimethyl-2,4-dihydro-pyrazol-3-one 
• 1010801-03-2 5-(2,3-Difluoro-4-methoxyphenyl)-4,4-dimethyl-2,4-dihydropyrazol-3-one 
• 1617504-91-2 (Z)-5-(10-hydroxy-11,12-difluorobenzylidene)imidazolidine-2,4-dione 

Relevant academic research and scientific papers

Phosphodiesterase inhibitors. Part 5: Hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration

(-)-6-(7-Methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl) -5-methyl-4,5-dihydropyridazin-3(2H)-one (KCA-1490) exhibits moderate dual PDE3/4-inhibitory activity and promises as a combined bronchodilatory/anti- inflammatory agent. N-alkylation of the pyridazinone ring markedly enhances potency against PDE4 but suppresses PDE3 inhibition. Addition of a 6-aryl-4,5-dihydropyridazin-3(2H)-one extension to the N-alkyl group facilitates both enhancement of PDE4-inhibitory activity and restoration of potent PDE3 inhibition. Both dihydropyridazinone rings, in the core and extension, can be replaced by achiral 4,4-dimethylpyrazolone subunits and the core pyrazolopyridine by isosteric bicyclic heteroaromatics. In combination, these modifications afford potent dual PDE3/4 inhibitors that suppress histamine-induced bronchoconstriction in vivo and exhibit promising anti-inflammatory activity via intratracheal administration.

Halogenated analogs of 1′-acetoxychavicol acetate, Rev-export inhibitor from Alpinia galanga, designed from mechanism of action

In the course of search for the robust analogs of 1′-acetoxychavicol acetate (ACA, 1), the Rev-export inhibitor from the medicinal plant Alpinia galanga, we clarified formation of the quinone methide intermediate ii to be essential for exerting the inhibi

PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT

It is to provide a novel pyrazolone derivative represented by the following general formula (1), which is useful as a pharmaceutical and has a phosphodiesterase inhibitory action: wherein R1,R2: C1-6 alkyl; R3,R4: H, X, C1-6 alkoxy; Z:O, S; A:AA, BB, wherein AA represents wherein BB represents wherein R5: H, C1-6 alkyl ; R6,R7: C1-6 alkyl.