6418-38-8Relevant articles and documents
19F NMR study on the biodegradation of fluorophenols by various Rhodococcus species
Bondar, Vladimir S.,Boersma, Marelle G.,Golovlev, Eugene L.,Vervoort, Jacques,Van Berkel, Willem J.H.,Finkelstein, Zoya I.,Solyanikova, Inna P.,Golovleva, Ludmila A.,Rietjens, Ivonne M.C.M.
, p. 475 - 486 (1998)
Of all NMR observable isotopes 19F is the one perhaps most convenient for studies on biodegradation of environmental pollutants. THe reasons underlying this potential of 19F NMR are discussed are illustrated on the basis of a study on the biodegradation of fluorophenols by four Rhodococcus strains. The results indicate marked differences between the biodegradation pathways of fluorophenols among the various Rhodococcus species. This holds not only for the level and nature of the fluorinated biodegradation pathway intermediates that accumulate, but also for the regioselectivity of the initial hyroxylation step. Several of the Rhodococcus species contain a phenol hydroxylase that catalyses the oxidative defluorination of ortho- fluorinated di- and trifluorophenols. Furthermore it is illustrated how the 19F NMR technique can be used as a tool in the process of identification of an accumulated unknown metabolite, in this case most likely 5- fluoromaleylacetate. Altogether, the 19F NMR technique proved valid to obtain detailed information on the microbial biodegradation pathways of fluorinated organics, but also provide information on the specificity of enzymes generally considered unstable and, for this reason, not much studied so far.
INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF
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Paragraph 00275, (2019/08/29)
The present application relates to compounds of Formula I (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.
A process for the preparation of 2, 3 - difluoro-phenol method (by machine translation)
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Paragraph 0039; 0041; 0044; 0047, (2018/10/19)
The invention relates to a process for preparing 2, 3 - difluoro of phenol, to 1, 2, 3 - trifluorobenzene as raw materials, the solid super strong alkali catalytic alkoxylated and dealkylating reaction to prepare 2, 3 - difluoro phenol, synthesis route is short, simple process operation, without special equipment, yield up to 94.8% or more, and has excellent industrial prospect. (by machine translation)
