676517-52-5

Upstream product

• 7686-77-3 3-cyclopentene-1-carboxylic acid 
• 245057-73-2 4-(3,4-dichloro-phenoxy)-piperidine 
• 3744-80-7 cyclopent-3-ene-1-carboxylic acid chloride 
• 676517-51-4 4-(3,4-dichlorophenoxy)-1-[1-oxo-2-(2-propenyl)-4-pentenyl]piperidine 

Downstream Products

• 676517-53-6 4-(3,4-dichlorophenoxy)-1-[(3,4-dihydroxycyclopentyl)carbonyl]piperidine 
• 921204-75-3 methyl (2S)-2-[4-[[4-(3,4-dichlorophenoxy)-1-piperidyl]methyl]-1-piperidyl]-2-methyl-3-phenylpropanoate 
• 921204-71-9 methyl (2S)-2-(4-{[4-(3,4-dichlorophenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate 
• 676518-10-8 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(S)-phenyl-1-piperidineacetic acid 
• 676517-70-7 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(R)-phenyl-1-piperidineacetic acid 
• 676517-69-4 methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(S)-phenyl-1-piperidineacetate 
• 676517-68-3 methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(R)-phenyl-1-piperidineacetate 
• 676517-50-3 4-[4-(3,4-dichloro-phenoxy)-piperidin-1-ylmethyl]-cyclopentane-1,2-diol 
• 770741-96-3 C₁₇H₂₁Cl₂NO₃ 

Relevant academic research and scientific papers

Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

The discovery and optimisation of a series of zwitterionic CCR3 antagonists is described. Optimisation of the structure led to AZ12436092, a compound with excellent selectivity over activity at hERG and outstanding pharmacokinetics in preclinical species.

CHEMICAL COMPOUNDS

The present invention provides a compound of a formula (I) wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.

NOVEL PIPERIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASE STATES

The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.