676518-75-5

Upstream product

• 676518-70-0 (S)-2-Amino-4-(2-amino-6-hydroxy-purin-9-yl)-3-hydroxy-butyric acid 
• 214604-57-6 (2-amino-6-hydroxy-purin-9-yl)-acetaldehyde 
• 10310-21-1 2-Amino-6-chloropurin 
• 28844-32-8 α-(2-amino-6-chloropurin-9-yl)acetaldehyde diethylacetal 
• 676518-74-4 1-O-(1-carboxylbutyl-4-oxyl) 2,3,4-tri-O-acetyl-α-L-fucopyranoside 
• 214604-62-3 (2S,3S)-2-Amino-4-(2-amino-6-hydroxy-purin-9-yl)-3-hydroxy-butyric acid benzyl ester 

Relevant academic research and scientific papers

Design and Synthesis of Peptide Mimetics of GDP-Fucose: Targeting Inhibitors of Fucosyltransferases

Novel peptide mimetics of GDP-fucose were designed and synthesized targeting inhibitors of the fucosyltransferases that transfer L-fucose from GDP-fucose to oligosaccharides, on the basis of the background that nikkomycin Z, a peptide mimetic of UDP-N-acetylglucosamine, shows potent inhibitory activity toward an N-acetylglucosamine transfer enzyme. The synthetic routes of the GDP-fucose mimetics take advantage of an enzymatic aldol reaction catalyzed by L-threonine aldolase to prepare the guanine carrying β-hydroxy-α- L-amino acid, a key synthetic intermediate.