676558-37-5

Usage

Type of compound

a derivative of pyrrolidine, an aldehyde with a dioxo functional group

Common uses

intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds

Potential applications

medicinal chemistry, drug development, and as a versatile building block in organic synthesis

Safety precautions

potential hazards associated with its use, proper safety measures should be followed when handling it.

Upstream product

• 18190-44-8 1-(2-Hydroxy-ethyl)-pyrrolidine-2,5-dione 

Downstream Products

• 676558-57-9 1-{2-[(E)-(S)-1-Phenyl-ethylimino]-ethyl}-pyrrolidine-2,5-dione 

Relevant academic research and scientific papers

Transition State-Based Sialyltransferase Inhibitors: Mimicking Oxocarbenium Ion by Simple Amide

In the new transition-state based sialyltransferase inhibitors, an amide group was placed at the corresponding C-2 position of CMP-sialic acid to mimic the geometry and charge distribution in the transition state, and simple aromatic or aliphatic rings were used instead of the sialic acid moiety. All synthetic compounds exhibited excellent α(2-6)-sialyltransferase inhibition, resulting in up to a 2600-fold higher affinity for the enzyme than CMP-Neu5Ac, suggesting that amide is a key element for simulating transition-state features.

The use of nonactivated iminodienophiles in the stereoselective aza-Diels-Alder reaction

This paper describes the preparation of nitrogen-containing bicycles by the aza-Diels-Alder reaction of nonactivated iminodienophiles and cyclopentadiene. Readily available starting materials such as (S)-(-)-lactate and L-amino acids were used for the pre