676604-36-7

Basic information

• Product Name: (E)-(S)-2,4-Bis-benzyloxy-7-methyl-7,8,9,10-tetrahydro-14H-6-oxa-benzocyclododecene-5,13-dione
• Synonyms: (E)-(S)-2,4-Bis-benzyloxy-7-methyl-7,8,9,10-tetrahydro-14H-6-oxa-benzocyclododecene-5,13-dione
• CAS NO: 676604-36-7
• Molecular Weight: 470.565
• Mol File: 676604-36-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-(S)-2,4-Bis-benzyloxy-7-methyl-7,8,9,10-tetrahydro-14H-6-oxa-benzocyclododecene-5,13-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-(S)-2,4-Bis-benzyloxy-7-methyl-7,8,9,10-tetrahydro-14H-6-oxa-benzocyclododecene-5,13-dione(676604-36-7)
• EPA Substance Registry System: (E)-(S)-2,4-Bis-benzyloxy-7-methyl-7,8,9,10-tetrahydro-14H-6-oxa-benzocyclododecene-5,13-dione(676604-36-7)

Safety Data

• Hazardous Substances Data: 676604-36-7(Hazardous Substances Data)

Upstream product

• 65756-08-3 (S)-(+)-6-Heptyn-2-ol 
• 1353016-49-5 (S)-7-(trimethylsilyl)hept-6-yn-2-ol 
• 201230-82-2 carbon monoxide 
• 676604-35-6 2,4-Bis-benzyloxy-6-chloromethyl-benzoic acid (S)-1-methyl-hex-5-enyl ester 
• 24395-10-6 (R)-hept-6-en-2-ol 
• 676604-27-6 2,4-Bis-benzyloxy-6-(2-oxo-but-3-enyl)-benzoic acid (S)-1-methyl-hex-5-enyl ester 

Downstream Products

• 676604-39-0 2,4-dihydroxy-7-methyl-11-phenylselanyl-7,8,9,10,11,12-hexahydro-14H-6-oxa-benzocyclododecene-5,13-dione 
• 676604-38-9 2,4-bis-benzyloxy-7-methyl-11-phenylselanyl-7,8,9,10,11,12-hexahydro-14H-6-oxa-benzocyclododecene-5,13-dione 

Relevant articles and documents

Total Synthesis of trans-Resorcylide via Macrocyclic Stille Carbonylation

The resorcylic macrolides are important natural products with a wide range of remarkable biological activities. So far, most of the reported resorcylic macrolide syntheses use either macrolactonization or ring closing metathesis to build the corresponding macrocycle. In continuation of our efforts in developing novel carbonylation reactions to facilitate natural product total synthesis, we report herein a total synthesis of trans-resorcylide (1) featuring a palladium-catalyzed macrocyclic Stille carbonylation to build its 12-membered macrocycle.