676604-36-7Relevant academic research and scientific papers
Total Synthesis of trans-Resorcylide via Macrocyclic Stille Carbonylation
Luo, Yiyang,Yin, Xianglin,Dai, Mingji
, p. 482 - 485 (2019/02/19)
The resorcylic macrolides are important natural products with a wide range of remarkable biological activities. So far, most of the reported resorcylic macrolide syntheses use either macrolactonization or ring closing metathesis to build the corresponding macrocycle. In continuation of our efforts in developing novel carbonylation reactions to facilitate natural product total synthesis, we report herein a total synthesis of trans-resorcylide (1) featuring a palladium-catalyzed macrocyclic Stille carbonylation to build its 12-membered macrocycle.
First Total Synthesis of trans- and cis-Resorcylide: Remarkable Hydrogen-Bond-Controlled, Stereospecific Ring-Closing Metathesis
Couladouros, Elias A.,Mihou, Anastasia P.,Bouzas, Emmanuel A.
, p. 976 - 980 (2007/10/03)
Stereospecific synthesis of the pair of natural macrolides, trans- and cis-resorcylide, was performed using ring-closing metathesis on dienes 3 and 4, which lack or feature an intramolecular H-bond, respectively. An effective Stille carbonylative
