67678-37-9Relevant academic research and scientific papers
Accessing α-Arylated Nitriles via BF3·OEt2 Catalyzed Cyanation of para-Quinone Methides Using tert-Butyl Isocyanide as a Cyanide Source
Shirsath, Sachin R.,Shinde, Ganesh H.,Shaikh, Aslam C.,Muthukrishnan
, p. 12305 - 12314 (2018/10/02)
BF3·OEt2 catalyzed 1,6-conjugate addition of tert-butyl isocyanide to para-quinone methides and fuchsones for the synthesis of α-diaryl and α-triaryl nitriles has been reported. This protocol allows α-diaryl- and α-triaryl nitriles to be accessed in good to excellent yields and with a broad substrate scope, which could be further functionalized to give a versatile set of products. This is the first example wherein tert-butyl isocyanide has been used as a cyanide source for the 1,6-conjugate addition.
N-Heterocyclic Carbene Catalyzed 1,6-Conjugate Addition of Me3Si-CN to para-Quinone Methides and Fuchsones: Access to α-Arylated Nitriles
Goswami, Prithwish,Singh, Gurdeep,Vijaya Anand, Ramasamy
supporting information, p. 1982 - 1985 (2017/04/27)
An organocatalytic approach toward α-arylated nitriles using N-heterocyclic carbene (NHC) as a catalyst is described. This protocol comprises an NHC catalyzed activation of Me3Si-CN followed by 1,6-conjugate addition of cyanide to para-quinone methides (p-QMs) and fuchsones leading to α-diaryl- and α-triaryl nitriles in good to excellent yields.
