6769-85-3

Upstream product

• 20911-65-3 N-Cbz-L-alanyl-L-phenylalanine succinimido ester 
• 113304-72-6 IPAoc-Met-OMe 
• 113304-71-5 IPAoc-Phe-Met-OMe 
• 3401-36-3 (N-benzyloxycarbonyl)-L-alanine N-hydroxysuccinimide ester 
• 3235-14-1 (S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-3-phenyl-propionic acid methyl ester 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 1142-20-7 N-Cbz-Ala 
• 2768-53-8 N-benzyloxycarbonyl-L-alanyl-L-phenylalanine 
• 2491-18-1 (S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride 

Downstream Products

• 1639120-81-2 Cbz-Ala-Phe-Met-Leu-OMe 

Relevant academic research and scientific papers

1-ISOPROPYLALLYLOXYCARBONYL (IPAoc) AS A PROTECTIVE GROUP OF AMINES AND ITS DEPROTECTION CATALYSED BY PALLADIUM-PHOSPHINE COMPLEX

As a new protective group of amines, 1-isopropylallyloxycarbonyl (IPAoc) group was developed.IPAoc group can be removed by treatment with a palladium-phosphine catalyst forming carbon dioxide and 4-methyl-1,3-pentadiene by the decarboxylation and β-hydrogen elimination of (?-1-isopropylallyl)-palladium intermediate under neutral condititons.The present protection-deprotection was applied to a one-pot peptide synthesis.

A one-pot saponification-coupling sequence suitable for C-terminus peptide elongation using lithium carboxylates

An efficient procedure has been developed for the saponification of common peptide esters, followed by straightforward coupling of the lithium carboxylate. Adding some water to the reaction medium gave faster saponification and did not interfere with the coupling reagent. As peptide chemistry constitutes a major application of the amidation reaction, amino acid substrates were chosen for this study, monitoring both yields and epimerization of the peptides obtained. Georg Thieme Verlag Stuttgart New York.