677-25-8

Basic information

• Product Name: ethylenesulphonyl fluoride
• Synonyms: ethylenesulphonyl fluoride;Ethenesulfonylfluoride;Ethenesulfonic acid fluoride;Fluorosulfonylethene;Ethenesulfonyl fluoride,97%;Vinyl sulfonyl fluoride
• CAS NO: 677-25-8
• Molecular Formula: C₂H₃FO₂S
• Molecular Weight: 194.1775664
• EINECS: 211-640-7
• Mol File: 677-25-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 116.1°C at 760 mmHg
• Flash Point: 40℃
• Appearance: /
• Density: 1.328 g/mL at 25 °C
• Vapor Pressure: 22mmHg at 25°C
• Refractive Index: n20/D1.385
• CAS DataBase Reference: ethylenesulphonyl fluoride(CAS DataBase Reference)
• NIST Chemistry Reference: ethylenesulphonyl fluoride(677-25-8)
• EPA Substance Registry System: ethylenesulphonyl fluoride(677-25-8)

Safety Data

• Hazard Codes: T,C
• Statements: 23/24/25-34-68
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2920 3(8) / PGII
• WGK Germany: 3
• Hazardous Substances Data: 677-25-8(Hazardous Substances Data)

Usage

General Description

Ethylenesulphonyl fluoride is a chemical compound with the molecular formula C2H3FO2S. It is a colorless, liquid organic compound with a sharp, pungent odor. Ethylenesulphonyl fluoride is primarily used as an intermediate in the manufacturing of pharmaceuticals, agrochemicals, and specialty chemicals. It is also utilized as a crosslinking agent in the production of polymers and as a solvent in various industrial applications. However, ethylenesulphonyl fluoride is considered to be a highly hazardous chemical and should be handled with extreme caution due to its potential to cause severe respiratory and skin irritation, as well as its highly reactive nature. Additionally, it is classified as a highly toxic and environmentally harmful substance, and its use is subject to strict regulations and safety measures.

InChI:InChI=1/C2H3FO2S/c1-2-6(3,4)5/h2H,1H2

Upstream product

• 762-70-9 2-chloroethanesulfonyl fluoride 
• 762-68-5 2-fluoroethanesulfonyl chloride 
• 1622-32-8 2-Chloroethanesulfonyl chloride 
• 54429-56-0 2-bromoethanesulfonyl chloride 
• 6608-47-5 vinylsulfonyl chloride 

Downstream Products

• 71517-42-5 2-(Phenylthio)ethansulfonylfluorid 
• 60353-82-4 2-(Methylphenylamino)ethansulfonylfluorid 
• 85582-50-9 2-cyclohexyl-1,2-thiazetidine 1,1-dioxide 
• 127364-22-1 2-[(4-bromophenyl)amino]ethanesulfonyl fluoride 
• 127364-21-0 2-[(4-nitrophenyl)amino]ethanesulfonyl fluoride 

Relevant articles and documents

Ethenesulfonyl Fluoride (ESF): An On-Water Procedure for the Kilogram-Scale Preparation

A two-step, on-water procedure for the synthesis of ethenesulfonyl fluoride (ESF) is described. 2-Chloroethanesulfonyl fluoride is made via a neat reaction with an aqueous, nearly saturated potassium bifluoride solution from readily available 2-chloroetha

Method for efficiently preparing sulfuryl fluorides compound by catalytic fluorination

The invention belongs to the technical field of the chemical synthesis, and particularly relates to a method for efficiently preparing a sulfuryl fluorides compound by catalytic fluorination. The provided method for efficiently preparing the sulfuryl fluorides compound by the catalytic fluorination comprises the following steps: enabling a sulfonyl chlorides compound to react with a hydroge fluoride under the action of a catalyst of a sulfonic acids derivative, to obtain the sulfuryl fluorides compound. A novel catalytic technology is provided, and the method has extensive substrate applicability. Efficient catalytic efficiency and yield are expressed.

Evaluation and biological properties of reactive ligands for the mapping of the glycine site on the N-methyl-D-aspartate (NMDA) receptor

The glycine-binding site of the N-methyl-D-aspartate (NMDA) receptor, given its potential as pharmacological target, has been thoroughly studied by structure-activity relationships, which has made possible its description in terms of spatial limits and interactions of various types. A structural model, based on mutational analysis and sequence alignments, has been proposed. Yet, the amino acid residues responsible for the interactions with the ligand have not been unambiguously characterized. To evidence nucleophilic pocket-lining residues, we have designed and synthesized reactive glycine-site ligands derived from 3-substituted 4-hydroxy-quinolin- 2(1H)-ones by introducing various electrophilic groups at different positions of the molecule. These ligands were found to have high affinity at the glycine site and to be functional antagonists by inhibiting glycine/glutamate-induced currents in transfected oocytes. The correlation between their potency and their substitution pattern was strictly consistent with previously established structure-activity relationships. Most ligands displayed intrinsic reactivity toward cysteine, but none inactivated wild- type receptors. This is consistent with the model since it indicates the absence of exposed cysteine in the glycine-binding site. A strategy of cysteine incorporation by point mutations at selected polypeptide positions will create unambiguously localized targets for our reactive probes.