85582-50-9Relevant articles and documents
β-Sultams, I: A facile synthesis of substituted 1,2-thiazetidine 1,1-dioxides
Meyle,Otto
, p. 281 - 283 (1983)
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Syntheses de β-sultames (thiazetidines-1,2 dioxyde-1,1)
Champseix, A.,Chanet, J.,Etienne, A.,Berre, A. Lemasson, J. C.,Napierala, C.,Vessiere, R.
, p. 463 - 472 (2007/10/02)
β-sultams (1,2-thiazetidine-1,1-dioxides) are easily prepared by 1-halogensulphonyl-2-aminoalkane cyclisation. Two processes based upon this principle have permitted the preparation of many variously N and C-substituted β-sultams. 1) In the first method 1-chlorosulphonyl-2-aminoalkane hydrochlorides, prepared from taurines or β-aminothiols, cyclised in the presence of base. 2) The second process involves the spontaneous cyclisation of 1-fluorosulphonyl-2-aminoalkanes prepared Michael addition of primary amines to 1-fluorosulphonylethene.