85582-50-9Relevant academic research and scientific papers
SYNTHESIS AND REACTIONS OF 4-(α-AMINOARYLIDENE)THIAZETIDINE 1,1-DIOXIDES
Plagge, Herbert,Otto, Hans-Hartwig
, p. 193 - 204 (2007/10/02)
β-Sultams react as highly potent sulfonyl analogues of β-lactams with aromatic nitriles to the title compounds (2).Hydrolysis, reduction, and reactions of 2 with acylating and alkylating agents are described.Some of the compounds show a weak β-lactamase i
Syntheses de β-sultames (thiazetidines-1,2 dioxyde-1,1)
Champseix, A.,Chanet, J.,Etienne, A.,Berre, A. Lemasson, J. C.,Napierala, C.,Vessiere, R.
, p. 463 - 472 (2007/10/02)
β-sultams (1,2-thiazetidine-1,1-dioxides) are easily prepared by 1-halogensulphonyl-2-aminoalkane cyclisation. Two processes based upon this principle have permitted the preparation of many variously N and C-substituted β-sultams. 1) In the first method 1-chlorosulphonyl-2-aminoalkane hydrochlorides, prepared from taurines or β-aminothiols, cyclised in the presence of base. 2) The second process involves the spontaneous cyclisation of 1-fluorosulphonyl-2-aminoalkanes prepared Michael addition of primary amines to 1-fluorosulphonylethene.
