6770-44-1Relevant academic research and scientific papers
Synthesis and plant growth promoting activity of polyhydroxylated ketones bearing the 5α-hydroxy-6-oxo moiety and cholestane side chain
Rosado-Abón, Anielka,De Dios-Bravo, Guadalupe,Rodríguez-Sotres, Rogelio,Iglesias-Arteaga, Martín A.
, p. 461 - 466 (2012/05/19)
Three polyhydroxylated ketones bearing the 5α-hydroxy-6-oxo moiety were obtained from cholesterol. Two of them show plant growth promoting activity in the bean's second internode bioassay. The obtained results indicate that the presence of the 5α-hydroxy-
Synthesis of cytotoxic 6E-hydroximino-4-ene steroids: Structure/activity studies
Deive,Rodríguez,Jiménez
, p. 2612 - 2618 (2007/10/03)
In an effort to determine the pharmaceutical utility and the structural requirements for activity against various tumor cell lines, several 6E-hydroximino-4-ene steroids with different side chains and degrees of unsaturation on ring A were synthesized in our laboratory. Evaluation of the synthesized compounds for cytotoxicity against P-388, A-549, HT-29, and MEL-28 tumor cells revealed that some important structural features are required for activity. The presence of a cholesterol-type side chain, which appears to play a major role in determining the biological activity, the existence of a ketone functionality at C-3, and an elevated degree of oxidation on ring A all result in higher bioctivity than other structural motifs.
Facile intramolecular ene reactions of steroidal unsaturated acyloins
Marples,Spilling
, p. 4017 - 4026 (2007/10/02)
The relatively low temperature (200°C) intramolecular ene reaction of 4,5-seco-5β-cholest-3-en-5-ol-6-one followed by in situ rearrangement affords 3-methyl-B-nor-5β-cholest-2-en-4-one and 5-hydroxy-5β-cholestan-6-one and supports the view that 3β-methyl-
