677027-77-9Relevant academic research and scientific papers
Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazolylpyrazolines Compounds Containing Ferrocene
Chen, Liqin,Duan, Huihui,Zhang, Xinyu,Zhang, Qiong,Huang, Hailian,Zhao, Junlong,Chen, Bang,Hua, Chengwen,Gou, Xiaofeng
, p. 1978 - 1985 (2018)
The synthesis of 1,3,4-thiadiazole skeleton compounds exhibiting high fungicidal activities has been demonstrated. Thirteen novel 1,3,4-thiadiazolyl-pyrazolines compounds containing ferrocene were designed and synthesized from the ferrocenylchalcones intermediates 3a–3m and the 2-hydrazino-5-phenyl-1,3,4-thiadiazole intermediate 8. All compounds were characterized by 1H NMR, 13C NMR, FT-IR spectra, and HR-MS, and the structure of one of the new compounds N-(4-phenyl-1,3,4-thiadiazol-2-yl)-3-ferrocenyl-5-phenyl-pyrazoline 9a was further determined by X-ray diffraction analysis. The preliminary results of a biological activity assay indicated that all the title compounds exhibited significant fungicidal activities against Pythium solani, Gibberella saubinetii, and Gibberella nicotiancola. Furthermore, compounds 9e and 9h displayed even higher fungicidal activities against the three fungal species compared with the control drug pyraclostrobin.
Synthesis, characterization, electrochemistry and optical properties of new 1,3,5-trisubstituted ferrocenyl pyrazolines and pyrazoles containing sulfonamide moiety
Kumar, Ch. Kiran,Trivedi, Rajiv,Ravi Kumar, K.,Giribabu, L.,Sridhar, B.
, p. 64 - 73,10 (2020/08/20)
This article describes the synthesis and characterization of a series of new 3-ferrocenyl-1-(4-sulphamylphenyl)-5-aryl-4,5-dihydro-1H-pyrazolines and the corresponding pyrazole derivatives derived from ferrocenyl chalcones and 4-hydrazino benzenesulfonamide hydrochloride. The compounds were characterized by spectroscopic means and the structure of the new ferrocenyl pyrazoline (3a) was determined by means of X-ray crystallography. The optical properties of these compounds were studied by means of UV/visible absorption spectroscopy and fluorescence spectroscopy (both steady state and time-resolved) in dichloromethane solvent. Electrochemical study revealed that all the compounds exhibited reversible oxidation behavior at 521-543 mV corresponding to ferrocene pyrazolines (3a-l) and 621-645 mV corresponding to ferrocene pyrazoles (4a-j) respectively, as confirmed by the ipc/ipa = 0.92-1.00.
