67705-17-3

Upstream product

• 67705-16-2 [2-Chloro-5-((E)-4-hydroxy-2-methyl-but-2-enyl)-3-methoxy-phenyl]-methyl-carbamic acid methyl ester 
• 82599-02-8 [5-(2-Benzenesulfonyl-2-methyl-pent-4-enyl)-2-chloro-3-methoxy-phenyl]-methyl-carbamic acid methyl ester 
• 82599-00-6 (2-Chloro-5-iodomethyl-3-methoxy-phenyl)-methyl-carbamic acid methyl ester 
• 6635-20-7 isonitrovanillin 
• 83163-84-2 4-Chloro-3-methoxy-5-nitro-benzaldehyde 
• 121-33-5 vanillin 
• 141206-80-6 2-(3-Amino-4-chloro-5-methoxy-phenyl)-1, 3-dioxolane 
• 141206-79-3 2-(3-Methoxy-4-chloro-5-nitro-phenyl)-1, 3-dioxolane 
• 141206-83-9 (2-Chloro-5-formyl-3-methoxy-phenyl)-methyl-carbamic acid methyl ester 
• 141206-81-7 (2-Chloro-5-[1,3]dioxolan-2-yl-3-methoxy-phenyl)-carbamic acid methyl ester 
• 141206-82-8 (2-Chloro-5-[1,3]dioxolan-2-yl-3-methoxy-phenyl)-methyl-carbamic acid methyl ester 

Downstream Products

• 67045-46-9 [2-Chloro-3-methoxy-5-((2E,4E)-2-methyl-6-oxo-hexa-2,4-dienyl)-phenyl]-methyl-carbamic acid methyl ester 
• 67705-16-2 [2-Chloro-5-((E)-4-hydroxy-2-methyl-but-2-enyl)-3-methoxy-phenyl]-methyl-carbamic acid methyl ester 
• 82599-04-0 {2-Chloro-3-methoxy-5-[(E)-2-methyl-4-(triphenyl-λ⁵-phosphanylidene)-but-2-enyl]-phenyl}-methyl-carbamic acid methyl ester 
• 74510-49-9 [5-((E)-4-Bromo-2-methyl-but-2-enyl)-2-chloro-3-methoxy-phenyl]-methyl-carbamic acid methyl ester 
• 82599-06-2 {5-[(2E,4E,11E)-(6R,9S,10S)-9-(tert-Butyl-dimethyl-silanyloxy)-6,7,7-trimethoxy-2,10,12-trimethyl-13-oxo-trideca-2,4,11-trienyl]-2-chloro-3-methoxy-phenyl}-methyl-carbamic acid methyl ester 
• 82599-07-3 (2E,9E,11E)-(4S,5S,8R)-5-(tert-Butyl-dimethyl-silanyloxy)-13-(4-chloro-3-methoxy-5-methylamino-phenyl)-7,7,8-trimethoxy-2,4,12-trimethyl-trideca-2,9,11-trien-1-ol 
• 82599-08-4 {(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol 
• 82599-16-4 (S)-3-{(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-3-hydroxy-propionic acid ethyl ester 
• 82599-05-1 {5-[(2E,4E,11E)-(6R,9S,10S)-9-(tert-Butyl-dimethyl-silanyloxy)-6,7,7,13,13-pentamethoxy-2,10,12-trimethyl-trideca-2,4,11-trienyl]-2-chloro-3-methoxy-phenyl}-methyl-carbamic acid methyl ester 
• 82599-18-6 (R)-3-(tert-Butyl-dimethyl-silanyloxy)-3-{(2S,3R)-3-[(6E,8E)-(1R,2R,5S)-2-(tert-butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-propionic acid 
• 82599-17-5 (R)-3-(tert-Butyl-dimethyl-silanyloxy)-3-{(2S,3R)-3-[(6E,8E)-(1R,2R,5S)-2-(tert-butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-propionic acid ethyl ester 
• 82599-15-3 (2R,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxirane-2-carbaldehyde 
• 57103-68-1 (+/-)-maytansinol 
• 74510-48-8 [2-Chloro-5-((Z)-4-hydroxy-2-methyl-but-2-enyl)-3-methoxy-phenyl]-methyl-carbamic acid methyl ester 

Relevant academic research and scientific papers

TOTAL SYNTHESIS OF MAYTANSINOIDS. APPROACH TO 4,6-BISDEMETHYLMAYTANSINE AND 4-DEMETHYLMAYTANSINE

A convergent strategy was elaborated to synthesize maytansine 1 and maytansinoids modified on the carbon skeleton, especially 4-demethylmaytansine 2, 6-demethylmaytansine 3, 4,6-bisdemethylmaytansine 4.In this paper, the feasibility of the project was verified by the preparation of key intermediates for the synthesis of 4,6-bisdemethylmaytansine and 6-demethylmaytansine.The C-1-N open chain compound 18 in the 4,6-bisdemethyl series was obtained.