74510-49-9

Upstream product

• 74510-48-8 [2-Chloro-5-((Z)-4-hydroxy-2-methyl-but-2-enyl)-3-methoxy-phenyl]-methyl-carbamic acid methyl ester 
• 141206-85-1 [2-Chloro-5-((Z)-4,4-diethoxy-2-methyl-but-1-enyl)-3-methoxy-phenyl]-methyl-carbamic acid methyl ester 
• 141206-81-7 (2-Chloro-5-[1,3]dioxolan-2-yl-3-methoxy-phenyl)-carbamic acid methyl ester 
• 141206-82-8 (2-Chloro-5-[1,3]dioxolan-2-yl-3-methoxy-phenyl)-methyl-carbamic acid methyl ester 
• 141206-83-9 (2-Chloro-5-formyl-3-methoxy-phenyl)-methyl-carbamic acid methyl ester 
• 141206-79-3 2-(3-Methoxy-4-chloro-5-nitro-phenyl)-1, 3-dioxolane 
• 141206-80-6 2-(3-Amino-4-chloro-5-methoxy-phenyl)-1, 3-dioxolane 
• 121-33-5 vanillin 
• 67705-17-3 [2-Chloro-3-methoxy-5-((Z)-2-methyl-4-oxo-but-2-enyl)-phenyl]-methyl-carbamic acid methyl ester 
• 83163-84-2 4-Chloro-3-methoxy-5-nitro-benzaldehyde 
• 6635-20-7 isonitrovanillin 
• 82599-02-8 [5-(2-Benzenesulfonyl-2-methyl-pent-4-enyl)-2-chloro-3-methoxy-phenyl]-methyl-carbamic acid methyl ester 
• 67705-17-3 [2-Chloro-3-methoxy-5-((E)-2-methyl-4-oxo-but-2-enyl)-phenyl]-methyl-carbamic acid methyl ester 
• 82599-00-6 (2-Chloro-5-iodomethyl-3-methoxy-phenyl)-methyl-carbamic acid methyl ester 

Downstream Products

• 141206-87-3 [5-((E)-5-Benzenesulfinyl-2-methyl-pent-2-enyl)-2-chloro-3-methoxy-phenyl]-methyl-carbamic acid methyl ester 
• 180865-96-7 {2-Chloro-3-methoxy-5-[(E)-2-methyl-5-((S)-toluene-4-sulfinyl)-pent-2-enyl]-phenyl}-methyl-carbamic acid methyl ester 
• 57103-68-1 (-)-maytansinol 
• 1054654-60-2 (E)-(3S,6S,7S)-8-(2-{(2E,4E)-(R)-6-[4-Chloro-3-methoxy-5-(methoxycarbonyl-methyl-amino)-phenyl]-1-methoxy-5-methyl-hexa-2,4-dienyl}-[1,3]dithian-2-yl)-3-hydroxy-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-oct-4-enoic acid 
• 75340-63-5 (E)-(3S,6S,7S)-3-(tert-Butyl-dimethyl-silanyloxy)-8-{2-[(2E,4E)-(R)-6-(4-chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-oct-4-enoic acid 
• 1053749-61-3 [2-Chloro-5-((2E,4E)-(R)-6-{2-[(E)-(2S,3S,6S)-8,8-diethoxy-6-hydroxy-2-(2-methoxy-ethoxymethoxy)-3,5-dimethyl-oct-4-enyl]-[1,3]dithian-2-yl}-6-methoxy-2-methyl-hexa-2,4-dienyl)-3-methoxy-phenyl]-methyl-carbamic acid methyl ester 
• 1055038-19-1 (E)-(3S,6S,7S)-3-(tert-Butyl-dimethyl-silanyloxy)-8-(2-{(2E,4E)-(R)-6-[4-chloro-3-methoxy-5-(methoxycarbonyl-methyl-amino)-phenyl]-1-methoxy-5-methyl-hexa-2,4-dienyl}-[1,3]dithian-2-yl)-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-oct-4-enoic acid 
• 1053634-29-9 C₄₆H₇₈ClNO₁₀S₂Si 
• 1053627-73-8 C₄₅H₇₆ClNO₁₀S₂Si 
• 82599-04-0 {2-Chloro-3-methoxy-5-[(E)-2-methyl-4-(triphenyl-λ⁵-phosphanylidene)-but-2-enyl]-phenyl}-methyl-carbamic acid methyl ester 
• 82599-06-2 {5-[(2E,4E,11E)-(6R,9S,10S)-9-(tert-Butyl-dimethyl-silanyloxy)-6,7,7-trimethoxy-2,10,12-trimethyl-13-oxo-trideca-2,4,11-trienyl]-2-chloro-3-methoxy-phenyl}-methyl-carbamic acid methyl ester 
• 82599-07-3 (2E,9E,11E)-(4S,5S,8R)-5-(tert-Butyl-dimethyl-silanyloxy)-13-(4-chloro-3-methoxy-5-methylamino-phenyl)-7,7,8-trimethoxy-2,4,12-trimethyl-trideca-2,9,11-trien-1-ol 
• 82599-08-4 {(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol 
• 82599-16-4 (S)-3-{(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-3-hydroxy-propionic acid ethyl ester 

Relevant academic research and scientific papers

TOTAL SYNTHESIS OF MAYTANSINOIDS. APPROACH TO 4,6-BISDEMETHYLMAYTANSINE AND 4-DEMETHYLMAYTANSINE

A convergent strategy was elaborated to synthesize maytansine 1 and maytansinoids modified on the carbon skeleton, especially 4-demethylmaytansine 2, 6-demethylmaytansine 3, 4,6-bisdemethylmaytansine 4.In this paper, the feasibility of the project was verified by the preparation of key intermediates for the synthesis of 4,6-bisdemethylmaytansine and 6-demethylmaytansine.The C-1-N open chain compound 18 in the 4,6-bisdemethyl series was obtained.

Synthesis of maytansinoids: the aromatic moiety of maytansine

A simple and novel synthesis of the tetrasubstituted aromatic compound related to the "western-southern" region of maytansine has been achieved.