67705-77-5 Usage
Description
3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE, also known as Bromo-PEG5-bromide, is a PEG (polyethylene glycol) linker containing two bromide groups. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions, and the hydrophilic PEG spacer increases solubility in aqueous media. It is a clear, colorless oil and is commonly used in various applications due to its unique properties.
Uses
Used in Pharmaceutical Industry:
3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a linker for drug conjugation and bioconjugation applications. The expression is: 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a linker for [application reason] to facilitate the attachment of drugs or biomolecules to PEG, enhancing their solubility, stability, and bioavailability.
Used in Chemical Synthesis:
3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a reagent in chemical synthesis for the formation of various compounds. The expression is: 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a reagent for [application reason] to participate in nucleophilic substitution reactions, allowing for the creation of new molecules with specific properties.
Used in Material Science:
3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a component in the development of novel materials with specific properties. The expression is: 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a component for [application reason] to contribute to the formation of materials with tailored characteristics, such as improved solubility or stability.
Used in Diagnostics:
3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a component in the development of diagnostic tools and assays. The expression is: 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a component for [application reason] to enable the detection and quantification of specific biomolecules or other targets in various diagnostic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 67705-77-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,7,0 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 67705-77:
(7*6)+(6*7)+(5*7)+(4*0)+(3*5)+(2*7)+(1*7)=155
155 % 10 = 5
So 67705-77-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H24Br2O5/c13-1-3-15-5-7-17-9-11-19-12-10-18-8-6-16-4-2-14/h1-12H2
67705-77-5Relevant articles and documents
An electrochemically controlled supramolecular zip tie based on host-guest chemistry of CB[8]
Barriada, Jose L.,Domarco, Olaya,Franchi, Paola,García, Marcos D.,Lucarini, Marco,Neira, Iago,Peinador, Carlos
supporting information, p. 5228 - 5233 (2020/07/23)
Three molecular threads incorporating two viologen units attached by an oligo-ethylene glycol chain of variable length and an electron rich naphthalene moiety were prepared. The internal viologen unit is connected to the naphthalene by a rigid linker that
Crown-ether-modified cyclic dipeptides as supramolecular chiral catalysts
Bérubé, Christopher,Voyer, Normand
, p. 184 - 195 (2017/10/26)
With the objective to develop supramolecular catalysts for useful chemical transformations, we report here a rapid and efficient solid-phase synthesis of novel cyclic dipeptides (crown-CDPs) with a diversity of L-DOPA derived crown ether substituents and
New dimeric carbazole-benzimidazole mixed ligands for the stabilization of human telomeric G-quadruplex DNA and as telomerase inhibitors. A remarkable influence of the spacer
Maji, Basudeb,Kumar, Krishan,Muniyappa,Bhattacharya, Santanu
supporting information, p. 8335 - 8348 (2015/08/03)
The development of G-quadruplex (G4) DNA binding small molecules has become an important strategy for selectively targeting cancer cells. Herein, we report the design and evolution of a new kind of carbazole-based benzimidazole dimers for their efficient telomerase inhibition activity. Spectroscopic titrations reveal the ligands high affinity toward the G4 DNA with significantly higher selectivity over duplex-DNA. The electrophoretic mobility shift assay shows that the ligands efficiently promote the formation of G4 DNA even at a lower concentration of the stabilizing K+ ions. The TRAP-LIG assay demonstrates the ligand's potential telomerase inhibition activity and also establishes that the activity proceeds via G4 DNA stabilization. An efficient nuclear internalization of the ligands in several common cancer cells (HeLa, HT1080, and A549) also enabled differentiation between normal HFF cells in co-cultures of cancer and normal ones. The ligands induce significant apoptotic response and antiproliferative activity toward cancer cells selectively when compared to the normal cells.
