67705-77-5

Usage

Uses

Used in Pharmaceutical Industry:
3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a linker for drug conjugation and bioconjugation applications. The expression is: 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a linker for [application reason] to facilitate the attachment of drugs or biomolecules to PEG, enhancing their solubility, stability, and bioavailability.
Used in Chemical Synthesis:
3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a reagent in chemical synthesis for the formation of various compounds. The expression is: 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a reagent for [application reason] to participate in nucleophilic substitution reactions, allowing for the creation of new molecules with specific properties.
Used in Material Science:
3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a component in the development of novel materials with specific properties. The expression is: 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a component for [application reason] to contribute to the formation of materials with tailored characteristics, such as improved solubility or stability.
Used in Diagnostics:
3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a component in the development of diagnostic tools and assays. The expression is: 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-BROMIDE is used as a component for [application reason] to enable the detection and quantification of specific biomolecules or other targets in various diagnostic applications.

InChI:InChI=1/C12H24Br2O5/c13-1-3-15-5-7-17-9-11-19-12-10-18-8-6-16-4-2-14/h1-12H2

Upstream product

• 42749-27-9 hexa(ethyleneglycol) ditosylate 
• 109789-40-4 3,6,9,12,15-pentaoxaheptadecane-1,17-diyl dimethanesulfonate 
• 2615-15-8 pentaethylene glycol 

Downstream Products

• 2615-15-8 pentaethylene glycol 
• 524728-95-8 C₆₈H₉₄O₁₁ 

Relevant academic research and scientific papers

An electrochemically controlled supramolecular zip tie based on host-guest chemistry of CB[8]

Three molecular threads incorporating two viologen units attached by an oligo-ethylene glycol chain of variable length and an electron rich naphthalene moiety were prepared. The internal viologen unit is connected to the naphthalene by a rigid linker that

COMPOUND, DECORATIVE MATERIAL, DECORATED ARTICLE, AND INK COMPOSITION

To provide a compound exhibiting golden glossiness and providing a film having flexibility.SOLUTION: There is provided a compound represented by the formula (1). Rand Rare each independently a substituted or unsubstituted C1 to 12 alkyl group, -(CH)-COO-R, -(CH)-O-R, -(CH)-CONH-R, -(CH)-CONH-(CH)-OH or the like; Rto Rare each independently a C1 to 6 alkyl group; nis an integer of 2 to 10; and mto mare integer of 1 to 6.SELECTED DRAWING: None

Crown-ether-modified cyclic dipeptides as supramolecular chiral catalysts

With the objective to develop supramolecular catalysts for useful chemical transformations, we report here a rapid and efficient solid-phase synthesis of novel cyclic dipeptides (crown-CDPs) with a diversity of L-DOPA derived crown ether substituents and

LOW MOLECULAR WEIGHT POLYETHYLENE GLYCOL DRUG CONJUGATES HAVING IMPROVED DRUG BIOLOGICAL ACTIVITY

Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug.

New dimeric carbazole-benzimidazole mixed ligands for the stabilization of human telomeric G-quadruplex DNA and as telomerase inhibitors. A remarkable influence of the spacer

The development of G-quadruplex (G4) DNA binding small molecules has become an important strategy for selectively targeting cancer cells. Herein, we report the design and evolution of a new kind of carbazole-based benzimidazole dimers for their efficient telomerase inhibition activity. Spectroscopic titrations reveal the ligands high affinity toward the G4 DNA with significantly higher selectivity over duplex-DNA. The electrophoretic mobility shift assay shows that the ligands efficiently promote the formation of G4 DNA even at a lower concentration of the stabilizing K+ ions. The TRAP-LIG assay demonstrates the ligand's potential telomerase inhibition activity and also establishes that the activity proceeds via G4 DNA stabilization. An efficient nuclear internalization of the ligands in several common cancer cells (HeLa, HT1080, and A549) also enabled differentiation between normal HFF cells in co-cultures of cancer and normal ones. The ligands induce significant apoptotic response and antiproliferative activity toward cancer cells selectively when compared to the normal cells.

Bifunctional thiosialosides inhibit influenza virus

We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of influenza virus. These first generation compounds show IC50 values ranging from low micromolar to high nanomolar in enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).

Synthesis of unique 17β-estradiol homo-dimers, estrogen receptors binding affinity evaluation and cytocidal activity on breast, intestinal and skin cancer cell lines

A rapid and efficient synthesis of a series of C2-symmetric 17β-estradiol homo-dimers is described. The new molecules are linked at position 17α of the steroid nucleus with either an alkyl chain or a polyethylene glycol chain. They are made from estrone in only five chemical steps with an overall yield exceeding 30%. The biological activity of these compounds was evaluated in vitro on estrogen dependent and independent (ER+ and ER-) human breast tumor cell lines: MCF-7 and MDA-MB-231. Some of the dimers present selective cytotoxic activity against the ER+ cell line. However, they are not very cytotoxic when compared to the antiestrogen tamoxifen. Unfortunately, they show only weak affinity for the estrogen receptor alpha (ERα) and no affinity for the estrogen receptor beta (ERβ). The new compounds were also tested on human intestinal (HT-29) cancer and on murine skin cancer (B16-F10) cell lines for further biological assessment. Interestingly, the dimers were found to be cytotoxic to the murine skin cancer cell line but were inactive towards the intestinal cancer cell line.

Design, synthesis, and characterization of peptide nanostructures having ion channel activity

We report the synthesis and the functional studies of multiple crown α-helical peptides designed to form artificial ion channels. The approach combines the versatility of solid phase peptide synthesis, the conformational predictability of peptidic molecul

Estrogen-linked platinum (II) complexes as anticancer agents

wherein n may be 1, 2, 3, 4 or 5 when X is O, wherein n may be 2/3, 1, 4/3, 5/3, 2, 7/3, 8/3, 3, or 10/3 when X is C, wherein o may be 1, 2 or 3, wherein Y may be O or 17β-OH, wherein R1 may be selected from the group consisting of H, a straight alkyl group of 1 to 5 carbon atoms, a branched alkyl group of 3 to 5 carbon atoms, wherein R2 may be selected for the group consisting of H, a straight alkyl group of 1 to 4 carbon atoms, a branched alkyl group of 3 or 4 carbon atoms, F, Cl, Br, I, —CF3, —NO2, —OR1, —COR1 and —CH2OH. These compounds possess anticancer activity against hormono-dependent breast, uterus as well as ovarian cancer.

A facile synthesis of C2-symmetric 17β-estradiol dimers

A rapid and efficient synthesis of a series of C2-symmetric 17β-estradiol dimers is described. The new molecules are linked at position 17α of the steroid nucleus with either an alkyl chain or a polyethylene glycol chain. They are made from estrone in five chemical steps with an overall yield exceeding 30%. The biological activity of these compounds was evaluated in vitro on estrogen dependent and independent (ER+ and ER-) human breast tumor cell lines: MCF-7 and MDA-MB-231. Some of the dimers present selective cytotoxic activity against the ER+ cell line.