(4R)-3-((2S)-3-mercapto-2-methylpropanoyl)-4-thiazolidinecarboxylic acid, commonly known as tiopronin, is a thiol-containing amino acid derivative with a versatile range of pharmacological properties. It is widely recognized for its chelating capabilities, particularly in binding to heavy metals and facilitating their removal from the body. Tiopronin's structure endows it with the ability to scavenge reactive oxygen species and inhibit the formation of inflammatory mediators, making it a promising candidate for various medical applications.
67714-46-9
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Basic information
- Product Name: (4R)-3-((2S)-3-mercapto-2-methylpropanoyl)-4- thiazolidinecarboxylic acid
- Synonyms: (4R)-3-((2S)-3-mercapto-2-methylpropanoyl)-4- thiazolidinecarboxylic acid;(4R)-3-[(S)-3-Mercapto-2-methyl-1-oxopropyl]-4-thiazolidinecarboxylic acid;SA-291;YM-689;YS-980
- CAS NO:67714-46-9
- Molecular Formula: C8H13NO3S2
- Molecular Weight: 235.3237
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 483.9°Cat760mmHg
- Flash Point: 246.5°C
- Appearance: /
- Density: 1.382g/cm3
- Vapor Pressure: 1.08E-10mmHg at 25°C
- Refractive Index: 1.597
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: (4R)-3-((2S)-3-mercapto-2-methylpropanoyl)-4- thiazolidinecarboxylic acid(CAS DataBase Reference)
- NIST Chemistry Reference: (4R)-3-((2S)-3-mercapto-2-methylpropanoyl)-4- thiazolidinecarboxylic acid(67714-46-9)
- EPA Substance Registry System: (4R)-3-((2S)-3-mercapto-2-methylpropanoyl)-4- thiazolidinecarboxylic acid(67714-46-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 67714-46-9(Hazardous Substances Data)
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67714-46-9 Usage
Uses
Used in Pharmaceutical Applications:Tiopronin is utilized as a chelating agent for the treatment of conditions such as cystinuria, rheumatoid arthritis, and Wilson's disease. Its ability to bind and remove heavy metals from the body plays a crucial role in managing these conditions.
Used in HIV-associated Nephropathy Treatment:
Tiopronin has demonstrated potential in the treatment of HIV-associated nephropathy, where it aids in mitigating the renal complications associated with the disease.
Used as a Protective Agent Against Radiation-Induced Damage:
Due to its antioxidant properties, tiopronin serves as a protective agent against radiation-induced damage, safeguarding cells and tissues from the harmful effects of radiation exposure.
Used in Antioxidant and Anti-Inflammatory Applications:
Tiopronin's capacity to scavenge reactive oxygen species and inhibit the formation of inflammatory mediators makes it a valuable compound in antioxidant and anti-inflammatory therapies, contributing to the treatment and management of various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 67714-46-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,7,1 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.Calculate Digit Verification of CAS Registry Number 67714-46:
(7*6)+(6*7)+(5*7)+(4*1)+(3*4)+(2*4)+(1*6)=149
149 % 10 = 9
So 67714-46-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H13NO3S2/c1-5(2-13)7(10)9-4-14-3-6(9)8(11)12/h5-6,13H,2-4H2,1H3,(H,11,12)/t5-,6+/m1/s1
67714-46-9Upstream product
67714-46-9Downstream Products
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(4R)-3-((2S)-3-mercapto-2-methylpropanoyl)-4- thiazolidinecarboxylic acid
