677320-68-2

Upstream product

• 14001-63-9 2-methylthio-4-methylpyrimidine 
• 403-33-8 methyl 4-flurobenzoate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 217661-99-9 1-(4-fluorophenyl)-2-(2-methylsulphanylpyrimidin-4-yl)-1-ethanone 

Downstream Products

• 755756-91-3 6-(4-fluorophenyl)-2-(hydroxy)-5-(2-methylsulfanylpyrimidin-4-yl)pyridine-3-carbonitrile 
• 677320-70-6 4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-2-methylsulfanyl-pyrimidine 

Relevant academic research and scientific papers

4-(pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6

Identification and structure-guided optimization of a series of 4-(pyrazol-4-yl)-pyrimidines as selective CDK4/6 inhibitors is reported herein. Several potency and selectivity determinants were established based on the X-ray crystallographic analysis of representative compounds bound to monomeric CDK6. Significant selectivity for CDK4/6 over CDK1 and CDK2 was demonstrated with several compounds in both enzymatic and cellular assays.

HETEROCYCLIC COMPOUNDS

New compounds of formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as p38 kinase inhibitors.

PYRAZOLE COMPOUNDS

The present invention relates to pyrazole compounds represented by the formula (I): ???wherein R1 represents phenyl which may be substituted, ???R2 represents H, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl or subs

PYRAZOLOPYRIDINE DERIVATES

New compounds of formula (I) and the salts, solvates and prodrugs thereof, wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as p38 kinase inhibitors.