677326-87-3Relevant academic research and scientific papers
Compounds as inhibitors of cell proliferation and viral infections
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Page/Page column 11, (2008/06/13)
The present invention relates to novel compounds of the general formula (I) and salts and physiologically functional derivatives thereof, ???whereinZis NH, or CH2 if Y is SO2Yis C=O, C=S, or SO2 if Z is CH2;Ais
Novel compounds as inhibitors of cell proliferation and viral infections
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Page/Page column 8, (2008/06/13)
The present invention relates to novel compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein Z is NH, or CH2 if Y is SO2 Y is C═O, C═S, or SO2 if Z is CH2; A
Sulfonyl-phenyl-ureido benzamidines: A novel structural class of potent antimalarial agents
Leban, Johann,Pegoraro, Stefano,Dormeyer, Matthias,Lanzer, Michael,Aschenbrenner, Andrea,Kramer, Bernd
, p. 1979 - 1982 (2007/10/03)
The high throughput in silico screening of a virtual library into the structure of the P. falciparum lactate dehydrogenase (LDH) with the 4SCan technology yielded a series of biphenyl urea compounds. These were chemically optimized to a new structural class of potent antimalarial agents. The compounds did not inhibit plasmodium LDH enough to fully explain their potency. Therefore we conclude that an unknown mode of action may be the cause of the antimalarial activity.
