6752-38-1 Usage
General Description
4-(Chlorosulfonyl) phenyl isocyanate is a chemical compound with the molecular formula C7H4ClNO4S. It is a clear to yellowish liquid, although it may also be found in crystalline form. This substance is used primarily in the field of organic synthesis, often functioning as a key reactant in the formation of other complex compounds. It is also used to create pigments, pharmaceutical intermediates, and biologically active compounds. However, caution is necessary during handling due to its highly reactive nature; it can be dangerous if inhaled, can cause burns and eye damage, and can also be hazardous to aquatic life. It should be stored under a dry inert gas and kept in a cool, dry place.
Check Digit Verification of cas no
The CAS Registry Mumber 6752-38-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,7,5 and 2 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6752-38:
(6*6)+(5*7)+(4*5)+(3*2)+(2*3)+(1*8)=111
111 % 10 = 1
So 6752-38-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H4ClNO3S/c8-13(11,12)7-3-1-6(2-4-7)9-5-10/h1-4H
6752-38-1Relevant articles and documents
Practical chemoenzymatic synthesis of a 3-pyridylethanolamino β3 adrenergic receptor agonist
Chung, John Y. L.,Ho, Guo-Jie,Chartrain, Michel,Roberge, Chris,Zhao, Dalian,Leazer, John,Farr, Roger,Robbins, Micheal,Emerson, Kateeta,Mathre, David J.,McNamara, James M.,Hughes, David L.,Grabowski, Edward J. J.,Reider, Paul J.
, p. 6739 - 6743 (2007/10/03)
A chemoenzymatic synthesis of β3 agonist 1 suitable for large scale preparation is described. The key chiral 3-pyridylethanolamine intermediate (R)-7 was prepared via an improved Neber rearrangement and a yeast-mediated asymmetric reduction. The tetrazolone fragment of the molecule was constructed via a dipolar cycloaddition between 1-(cyclopentyl)-3-propylazide and p-chlorosulfonyl phenylisocyanate. Sulfonamide coupling of these two intermediates under Shotten-Baumann conditions, followed by a borane reduction of the amide afforded 1 in 20-32% overall yield from 3-acetylpyridine.
