677341-82-1Relevant academic research and scientific papers
Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)
Velaparthi, Upender,Wittman, Mark,Liu, Peiying,Stoffan, Karen,Zimmermann, Kurt,Sang, Xiaopeng,Carboni, Joan,Li, Aixin,Attar, Ricardo,Gottardis, Marco,Greer, Ann,Chang, ChiehYing Y.,Jacobsen, Bruce L.,Sack, John S.,Sun, Yax,Langley, David R.,Balasubramanian, Balu,Vyas, Dolatrai
, p. 2317 - 2321 (2008/02/01)
The discovery and synthesis of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor 1-receptor (IGF-1R) are presented. Installing amine containing side chains at the 4-position of pyridone ring significantly improved the
Benzimidazole C-2 heterocycles as kinase inhibitors
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Page/Page column 14, (2010/02/11)
Benzimidazole derivatives having the general formula I are provided. These compounds are useful as tyrosine kinase inhibitors, especially for the treatment of cancer.
Novel tyrosine kinase inhibitors
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Page 25, (2010/11/30)
The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inhibiting tyrosine kinase enzymes.
