131885-95-5

Upstream product

• 102791-92-4 1-(3-methyl-4-nitro-phenyl)-1H-imidazole 
• 118111-96-9 4-imidazol-1-yl-2-methyl-phenylamine 
• 677341-82-1 N-(4-imidazol-1-yl-2-methyl-6-nitro-phenyl)-acetamide 
• 468740-97-8 C₁₂H₁₃N₃O 
• 468740-98-9 4-imidazol-1-yl-2-methyl-6-nitro-phenylamine 
• 131885-45-5 5-imidazol-1-yl-3-methyl-2-nitroaniline 
• 131885-36-4 5-chloro-3-methyl-2-nitroaniline 
• 118665-00-2 2,4-dichloro-6-methylnitrobenzene 
• 446-33-3 5-Fluoro-2-nitrotoluene 
• 928261-59-0 2,2,2-trifluoro-N-(4-imidazol-1-yl-2-methyl-6-nitro-phenyl)-acetamide 

Relevant academic research and scientific papers

Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase

A novel class of 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase is described. This report discusses the SAR of 4-(2-hydroxy-2-phenylethylamino)-substituted pyridones with improved IGF-1R potency.

Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)

The discovery and synthesis of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor 1-receptor (IGF-1R) are presented. Installing amine containing side chains at the 4-position of pyridone ring significantly improved the

Benzimidazole C-2 heterocycles as kinase inhibitors

Benzimidazole derivatives having the general formula I are provided. These compounds are useful as tyrosine kinase inhibitors, especially for the treatment of cancer.

Novel tyrosine kinase inhibitors

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inhibiting tyrosine kinase enzymes.

Cardiotonic Agents. Synthesis and Cardiovascular Properties of Novel 2-Arylbenzimidazoles and Azabenzimidazoles

Novel 2-arylbenzimidazoles and azabenzimidazoles were synthesized, and their inotropic action was evaluated.Changes in left ventricular pressure, dP/dt max, were measured as an index of cardiac contractility.The structural features that impart optimal inotropic activity are presented.The most potent compounds were evaluated orally in conscious dogs with implanted Konigsberg pressure transducers.To investigate the mechanism of action, the most potent compounds were tested for their calcium-sensitizing properties and their potential for the inhibition of phosphodiesterase.Two compounds, 1 and 41, showed interesting in vitro and oral activity without side effects.They have a more potent calcium-sensitizing effect than MCI-154 and are under further investigation.