677352-87-3

Upstream product

• 287967-74-2 (2R,3R,4S,5S,6R)-2-(acetoxymethyl)-6-(4-iodophenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 540-38-5 p-Iodophenol 
• 83-87-4 D-Mannose pentaacetate 
• 694520-16-6 C₂₅H₃₂O₁₀Si 

Downstream Products

• 1318797-55-5 bis[4-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)phenyl]buta-1,3-diyne 
• 871311-10-3 bis[4-(α-D-mannopyranosyloxy)phenyl]buta-1,3-diyne 

Relevant academic research and scientific papers

Synthesis of a small library of bivalent α-d-mannopyranosides for lectin cross-linking

A small library of bivalent α-d-mannopyranosides having rigid linkers was constructed in order to evaluate the effects of inter-saccharide distances upon multivalent binding interactions with plant and bacterial lectins. To this end, iodoaryl and propargyl α-d-mannopyranosides were synthesized and the former treated with TMS-acetylene under palladium chemistry to provide their corresponding ethynylaryl derivatives. A library of 15 dimeric members was then obtained using Lewis acid catalyzed glycosidation, aryl-aryl homocoupling, transition metal catalyzed Sonogashira cross-coupling reactions, and oxidative Glaser homocoupling.