67736-22-5

Upstream product

• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 66056-40-4 2-(2,4-bis(benzyloxy)phenyl)acetic acid 
• 863310-62-7 (E)-β-[2-hydroxy-4-benzyloxyphenylethylene]-2,4-dibenzyloxybenzeneethanol 
• 863310-46-7 3-(2,4-dibenzyloxyphenyl)-7-benzyloxy-2H-1-benzopyran-2-one 
• 193008-72-9 3-(2,4-bis-benzyloxy-phenyl)-7-hydroxy-chromen-2-one 
• 863310-54-7 2-(2,4-dibenzyloxyphenyl)-6-benzyloxybenzofuran 
• 1855-30-7 1-(2,4-dihydroxyphenyl)-2-(2,4-dimethoxyphenyl)ethanone 

Downstream Products

• 67685-23-8 2-(2,4-dimethoxy-phenyl)-6-methoxy-benzofuran 

Relevant academic research and scientific papers

A short-step convenient synthesis of 2-phenylbenzofuran from 3-phenylcoumarin

The reaction mechanism of chemical conversion of (E)-β-[2-hydroxylphenylethylene]benzeneethanol into 2-phenylbenzofuran by DDQ, which involves loss of one carbon unit, was characterized and described. Five naturally occurring 2-phenylbenzofurans of not only the isoflavonoid but also stilbenoid origin were synthesized by use of this chemical scheme, which proved that this new scheme is a useful tool for quick synthesis of 2-phenylbenzofurans.

Synthesis of 5-Deoxykievitone Dimethyl Ether and Related Isopentenylated Isoflavanones

Three different 7-hydroxyisoflavanones (1a, 1b and 1c) have been converted into the corresponding 6'',6''-dimethylpyranoisoflavanones (4a, 4b and 4c) either through their 8-(3,3-dimethylallyl) derivatives (2a, 2b and 2c) or their 1,1-dimethylpropargyl ethers (3a, 3b and 3c).Among them, 2c is the dimethyl ether of naturally occurring 5-deoxykievitone.Attempts to synthesize the natural product itself by this route have been unsuccessful because demethylation of the starting desoxybenzoin (5) gives the corresponding 2-arylbenzofuran derivative (7a).