6775-66-2

Usage

Uses

Used in Antimicrobial Applications:
2,5-Dichlorobenzenesulfonohydrazide is used as an antimicrobial agent for inhibiting the growth and reproduction of microorganisms. Its effectiveness in controlling microbial populations makes it suitable for use in products such as paints, adhesives, and textiles, where preventing microbial growth is essential for maintaining product integrity and performance.
Used in Fungicidal Applications:
In agricultural settings, 2,5-dichlorobenzenesulfonohydrazide serves as a fungicide, protecting crops from fungal infections that can lead to reduced yields and quality. Its ability to target and inhibit fungal growth contributes to more robust and healthier plants, ultimately benefiting the agricultural industry.
Used in Polymer Material Manufacturing:
2,5-Dichlorobenzenesulfonohydrazide is also utilized in the production of polymer materials, where its antimicrobial and fungicidal properties can enhance the durability and resistance of the final product against microbial and fungal degradation.
Used as a Chemical Intermediate:
Furthermore, 2,5-dichlorobenzenesulfonohydrazide functions as a chemical intermediate in the synthesis of other organic compounds. Its role in the chemical industry is crucial for the development of new products and the improvement of existing ones.

Upstream product

• 5402-73-3 2,5-dichlorobenzenesulphonyl chloride 

Downstream Products

• 88522-51-4 C₁₃H₁₀Cl₂N₂O₃S 
• 88522-47-8 C₁₃H₁₂Cl₂N₂O₄S₂ 
• 1554261-73-2 C₁₆H₁₆Cl₂OS 
• 88522-19-4 N,N-dimethyl-2,5-dichlorobenzenesulfonamide 
• 6647-37-6 2,5?dichloro?N’?(1?phenylethylidene)benzenesulfonohydrazide 
• 1448709-50-9 C₁₄H₉Cl₂NS 
• 59425-77-3 C₁₄H₁₀Cl₂ 
• 76089-71-9 2,5-dichloro-stilbene 
• 75968-23-9 glyoxylic acid 2,5-dichlorobenzenesulfonylhydrazone 
• 88522-50-3 C₁₃H₉Cl₂N₃O₄S 

Relevant academic research and scientific papers

One-pot synthesis of sulfonylhydrazones from sulfonyl chloride, hydrazine hydrate and vinyl azide in water

A facile and eco-friendly protocol for the synthesis of sulfonylhydrazones from sulfonyl chlorides, hydrazine hydrate and vinyl azides was developed. The unique advantage of this approach is that desired products can be obtained efficiently in water, which meets the requirements of green chemistry and provides good perspectives for the sustainable production of new drug candidate. Also, this reaction proceeded in moderate to good yields with a wide tolerance of functional groups.

Synthesis, in vitro α-amylase inhibitory, and radicals (DPPH & ABTS) scavenging potentials of new N-sulfonohydrazide substituted indazoles

Over-expression of α-amylase enzyme causes hyperglycemia which lead to many physiological complications including oxidative stress, one of the most commonly associated problem with diabetes mellitus. Marketed α-amylase inhibitors such as acarbose, voglibose, and miglitol used to treat type-II diabetes mellitus, but also linked to several harmful effects. Therefore, it is essential to explore new and nontoxic antidiabetic agents with additional antioxidant properties. In this connection, a series of new N-sulfonohydrazide substituted indazoles 1–19 were synthesized by multistep reaction scheme and assessed for in vitro α-amylase inhibitory and radical (DPPH and ABTS) scavenging properties. All compounds were fully characterized by different spectroscopic techniques including 1H, 13C NMR, EI-MS, HREI-MS, ESI-MS, and HRESI-MS. Compounds showed promising α-amylase inhibitory activities (IC50 = 1.23 ± 0.06–4.5 ± 0.03 μM) as compared to the standard acarbose (IC50 1.20 ± 0.09 μM). In addition to that all derivatives were found good to moderate scavengers of DPPH (IC50 2.01 ± 0.13–5.3 ± 0.11) and ABTS (IC50 = 2.34 ± 0.07–5.5 ± 0.07 μM) radicals, in comparison with standard ascorbic acid having scavenging activities with IC50 = 1.99 ± 0.09 μM, and IC50 2.03 ± 0.11 μM for DPPH and ABTS radicals. In silico molecular docking study was conducted to rationalize the binding interaction of α-amylase enzyme with ligands. Compounds were observed as mixed type inhibitors in enzyme kinetic characterization.

An approach to C-N activation: Coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with: Tert -amines via a metal-, oxidant- and halogen-free anodic oxidation

tert-Amines were harnessed to afford arenesulfonyl hydrazides and arenesulfonyl chlorides via a metal-, oxidant- and halogen-free electrochemical oxidative coupling in an undivided cell at RT. This environmentally benign approach afforded a wide spectrum of sulfonamides in satisfactory yields using cheap and renewable Pencil Graphite Electrodes (PGEs).

Oxidative Mizoroki-Heck-type reaction of arylsulfonyl hydrazides for a highly regio- and stereoselective synthesis of polysubstituted alkenes

A useful source: Arylsulfonyl hydrazides have been identified as synthetically useful aryl sources for the Pd(OAc)2 catalyzed oxidative Mizoroki-Heck-type reaction under molecular oxygen to provide a convenient access to polysubstituted alkenes in a highly regio- and stereoselective manner (see scheme). The reaction well tolerates various functional groups such as alkoxy, halo, alcohol, carboxylic acid, ester, amide, sulfonamide, and sulfone. Copyright

N-arylsulfonyl hydrazones as inhibitors of IMP-1 metallo-β-lactamase

Members of a family of N-arylsulfonyl hydrazones have been identified as novel inhibitors of IMP-1, a metallo-β-lactamase of increasing prevalence. Structure-activity relationship studies have indicated a requirement for bulky aromatic substituents on each side of the sulfonyl hydrazone backbone for these compounds to serve as efficient inhibitors of IMP-1. Molecular modeling has provided insight into the structural basis for the anti-metallo-β-lactamase activity exhibited by this class of compounds.

2,5-Dichlorobenzenesulphonamide Derivatives and Their Biological Activities

2,5-Dichlorobenzenesulphonyl chloride (I) reacts with p-aminobenzoic acid to give IXc from which the corresponding esters (X), primary (XI) and secondary (XII) amides have been prepared.Reaction of I with hydrazine hydrate furnishes two hydrazides (XVIIIa