67751-14-8

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 4-(DIMETHYLAMINO)-2-OXOBUT-3-ENOATE is used as a reagent in the pharmaceutical industry for the preparation of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the synthesis of drugs with specific therapeutic properties.
Used in Research Chemicals:
In the field of research, ETHYL 4-(DIMETHYLAMINO)-2-OXOBUT-3-ENOATE is employed as a reagent for the preparation of research chemicals. Its versatility in organic synthesis makes it valuable for the development of new chemical entities and the study of their properties and potential applications.
Used as a Precursor in Organic Synthesis:
ETHYL 4-(DIMETHYLAMINO)-2-OXOBUT-3-ENOATE is used as a precursor in the synthesis of other important organic compounds. Its ability to participate in various chemical reactions makes it a valuable building block for the creation of complex organic molecules with diverse applications across different industries.

InChI:InChI=1/C8H13NO3/c1-4-12-8(11)7(10)5-6-9(2)3/h5-6H,4H2,1-3H3/b6-5+

Upstream product

• 617-35-6 2-oxo-propionic acid ethyl ester 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 122831-02-1 t-butyl 4-dimethylamino-2-oxo-3-butenoate 
• 76849-54-2 t-butyl pyruvate 

Downstream Products

• 67750-78-1 C₁₆H₁₈N₂O₂ 
• 361436-79-5 2-[4-(4-chloro-2-fluorophenoxy)phenyl]pyrimidine-4-carboxamide 
• 250726-39-7 ethyl-2-methylsulfanylpyrimidine-4-carboxylate 
• 253769-50-5 ethyl 2-phenylpyrimidine-4-carboxylate 
• 115342-26-2 ethyl 1–(4-bromophenyl)-1H-pyrazole-5-carboxylate 
• 1423701-76-1 C₂₄H₂₄N₂O₄ 
• 5932-27-4 ethyl 1H-pyrazole-3-carboxylate 
• 1185016-32-3 ethyl 2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-pyrimidine-4-carboxylate 
• 122831-18-9 diethyl 2-(dimethylamino)-5-(benzylthio)-2,4-hexadienedioate 
• 129363-78-6 ethyl 2-(dimethylamino)-6-phenyl-6-oxo-5-(phenylthio)-2,4-hexadienoate 
• 122831-03-2 (2E,4Z)-2-Dimethylamino-5-phenylsulfanyl-hexa-2,4-dienedioic acid diethyl ester 
• 122830-59-5 (2Z,4E)-2-Benzylsulfanyl-5-hydroxy-hexa-2,4-dienedioic acid diethyl ester 
• 129363-79-7 diethyl 5-benzoyl-2-(dimethylamino)-2,4-hexadienedioate 

Relevant academic research and scientific papers

2-trifluoromethylpyrimidin-4-carboxylic acid and its derivatives and preparation method thereof

The invention relates to 2-trifluoromethylpyrimidin-4-carboxylic acid with a general formula (I) and its derivatives. In the general formula (I), R represents COOH, COOX, COORn, COOCH3, COOCH2CH3 or CH2OH, X represents any alkali or amine which can react with a strong acid or carboxylic acid to produce a salt and Rn represents any carbonyl compound. The invention also relates to a preparation method of the compound. The preparation method has good controllability, mainly solves the technical problem of large-scale production limitation and has a good application prospect.

LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.

MODULATORS OF CXCR7

Compounds having formula (I) or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present inven

SYNTHESIS OF 2-ARYL PYRIMIDINE 4-CARBOXYLIC ACID AMIDES

Disclosed is a method for the preparation of 2-aryl pyrimidine 4 carboxylic acid amides by reacting an aryl carboxamidine with a 4 substituted 2-oxo-3-butenyl amide. Also disclosed is a method for the preparation of 2-aryl pyrimidine 4 carboxylic acid ami

Alkadiene derivatives, their preparation, and pharmaceutical compositions containing them

Substituted alkadienes of the formula: STR1 in which R1 is hydroxy or acetoxy, R2 is hydrogen, carboxy, alkoxycarbonyl, phenyl or benzoyl, and R3 is alkylthio or alkoxy and R4 is naphthoyl or optionally substituted benzoyl, or R3 is alkoxycarbonyl, cycloalkyloxycarbonyl or cyano and R4 is alkyl, naphthyl, optionally substituted phenyl, alkylthio, naphthylmethanethio, optionally substituted benzylthio, optionally substituted phenylthio, naphthylthio, phenethylthio or allylthio, or R3 and R4 form, with the carbon atom to which they are attached, a ring-system of formula: STR2 in which R5 is hydrogen or alkoxy and X is methylene or S inhibit 5-lipoxygenase and are useful, for example, as anti-inflammatories.