76849-54-2

Basic information

• Product Name: Propanoic acid, 2-oxo-, 1,1-dimethylethyl ester
• Synonyms: 2-oxopropionic acid tert-butyl ester;tert. Butyl-pyruvat;Propanoic acid,2-oxo-,1,1-dimethylethyl ester;t-butyl pyruvate;pyruvate tert-butyl ester;tert-butyl pyruvate
• CAS NO: 76849-54-2
• Molecular Formula: C7H12O3
• Molecular Weight: 144.17
• Mol File: 76849-54-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 177.2±9.0 °C(Predicted)
• Density: 0.996±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Propanoic acid, 2-oxo-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-oxo-, 1,1-dimethylethyl ester(76849-54-2)
• EPA Substance Registry System: Propanoic acid, 2-oxo-, 1,1-dimethylethyl ester(76849-54-2)

Safety Data

• Hazardous Substances Data: 76849-54-2(Hazardous Substances Data)

Upstream product

• 127-17-3 2-oxo-propionic acid 
• 115-11-7 isobutene 
• 507-19-7 t-butyl bromide 
• 62163-16-0 silver pyruvate 
• 87670-15-3 2-[(E)-1-Methyl-2-phenyl-ethylimino]-propionic acid tert-butyl ester 
• 177540-33-9 2-(Methyl-p-tolyl-hydrazono)-propionic acid tert-butyl ester 
• 20487-40-5 tert-butyl propionate 
• 177540-32-8 2-(p-Tolyl-hydrazono)-propionic acid tert-butyl ester 
• 21691-50-9 Ala-OtBu 
• 59903-79-6 (S)-2-(1-Methyl-2-phenyl-ethylamino)-propionic acid tert-butyl ester 
• 59903-66-1 (S)-2-[1-Methyl-2-phenyl-eth-(Z)-ylideneamino]-propionic acid tert-butyl ester 
• 87669-90-7 C₁₆H₂₄ClNO₂ 
• 39061-59-1 t-butoxalyl chloride 
• 1218815-84-9 mono-tert-butyl oxalic acid N-methoxy-N-methylamide 

Downstream Products

• 60-35-5 acetamide 
• 17356-08-0 thiourea 
• 115-11-7 isobutene 
• 67751-14-8 ethyl 4-(dimethylamino)-2-oxo-3-butenoate 
• 648424-78-6 (R)-tert-butyl 2-hydroxy-2-phenylpropanoate 
• 885316-13-2 (S)-tert-butyl 2-hydroxy-2-phenylpropanoate 
• 585-07-9 tert-Butyl methacrylate 
• 21691-50-9 Ala-OtBu 
• 16367-69-4 tert-butyl D-alaninate 
• 1520094-29-4 (3R,4S,5S)-tert-butyl-5-benzyloxy-2-hydroxy-2,3-dimethyl-4-oxohexanoate 
• 1217887-69-8 (2R,3S)-tert-butyl 3-(dimethylcarbamoyl)-3-(4-methoxyphenoxy)-2-hydroxy-2-methylpropanoate 
• 1217887-65-4 (2R,3S)-tert-butyl 3-(dimethylcarbamoyl)-2-hydroxy-2-methyl-3-phenoxypropanoate 
• 68166-83-6 D-lactic acid t-butyl ester 
• 13650-70-9 (+)-tert-butyl D-lactate 

Relevant articles and documents

Interaction of Pyruvate-Thiamine Diphosphate Adducts with Pyruvate Decarboxylase. Catalysis through "Closed" Transition States

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Selective Carbonyl?C(sp3) Bond Cleavage To Construct Ynamides, Ynoates, and Ynones by Photoredox Catalysis

Carbon–carbon bond cleavage/functionalization is synthetically valuable, and selective carbonyl?C(sp3) bond cleavage/alkynylation presents a new perspective in constructing ynamides, ynoates, and ynones. Reported here is the first alkoxyl-radical-enabled carbonyl?C(sp3) bond cleavage/alkynylation reaction by photoredox catalysis. The use of novel cyclic iodine(III) reagents are essential for β-carbonyl alkoxyl radical generation from β-carbonyl alcohols, including alcohols with high redox potential (EoxP>2.2 V vs. SCE in MeCN). β-Amide, β-ester, and β-ketone alcohols yield ynamides, ynoates, and ynones, respectively, for the first time, with excellent regio- and chemoselectivity under mild reaction conditions.

ORALLY ADMINISTRABLE VIRIDIOFUNGIN DERIVATIVE HAVING ANTI-HCV ACTIVITY

An object of the present invention is to provide a compound that is useful as an orally available anti-HCV agent. The present invention relates to a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. This compound has an anti-HCV activity and is useful as a medicine.