67755-97-9

Basic information

• Product Name: 2-hydroxy-3-methylbutyraldehyde
• Synonyms: 2-hydroxy-3-methylbutyraldehyde;2-Hydroxy-3-methylbutanal
• CAS NO: 67755-97-9
• Molecular Formula: C₅H₁₀O₂
• Molecular Weight: 102.1317
• EINECS: 267-000-2
• Mol File: 67755-97-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 143°C at 760 mmHg
• Flash Point: 48.4°C
• Appearance: /
• Density: 0.957g/cm³
• Vapor Pressure: 2.19mmHg at 25°C
• Refractive Index: 1.417
• PKA: 13.28±0.20(Predicted)
• CAS DataBase Reference: 2-hydroxy-3-methylbutyraldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-3-methylbutyraldehyde(67755-97-9)
• EPA Substance Registry System: 2-hydroxy-3-methylbutyraldehyde(67755-97-9)

Safety Data

• Hazardous Substances Data: 67755-97-9(Hazardous Substances Data)

Usage

General Description

2-hydroxy-3-methylbutyraldehyde is a chemical compound with the molecular formula C5H10O2. It is a colorless liquid with a pungent, fruity odor, and is commonly used as a flavoring agent in the food industry. It is also used in the synthesis of pharmaceuticals and fragrances. Additionally, 2-hydroxy-3-methylbutyraldehyde is a key intermediate in the production of the artificial sweetener sucralose. The compound is considered to be relatively stable, but it can react with oxidizing agents and strong acids, posing potential hazards in certain industrial settings. Overall, 2-hydroxy-3-methylbutyraldehyde is a versatile chemical with various applications in the food, pharmaceutical, and fragrance industries.

InChI:InChI=1/C5H10O2/c1-4(2)5(7)3-6/h3-5,7H,1-2H3

Upstream product

• 67755-91-3 2-(1-ethoxy-ethoxy)-3-methyl-butyraldehyde 
• 590-86-3 isovaleraldehyde 
• 1095616-48-0 (E)-3-methylbut-1-enyl methanesulfonate 
• 67755-86-6 2-(1-ethoxy-ethoxy)-3-methyl-butyronitrile 
• 15344-34-0 2-hydroxy-3-methylbutanenitrile 
• 74031-61-1 1-Phenylsulfinyl-2-isopropylethylen 
• 435344-71-1 methyl 2-[(tert-butyldimethylsilyl)oxy]-3-methylbutanoate 
• 17417-00-4 methyl 2-hydroxy-3-methylbutanoate 
• 79-83-4 pantothenic acid 
• 563-45-1 3-Methyl-1-butene 
• 127896-21-3 2-<(tert-Butyldimethylsilyl)oxy>-3-methylbutanal 
• 132531-77-2 3-methyl-1-(phenylsulfenyl)-1,2-bis(trifluoroacetoxy)butane 

Relevant articles and documents

Influence of α-methyl substitution of proline-based organocatalysts on the asymmetric α-oxidation of aldehydes

The direct asymmetric organocatalytic α-oxidation of aldehydes using trans-2-(p-methylphenylsulfonyl)-3-phenyloxaziridine is reported. This method affords the S isomer of α-hydroxy aldehydes, thereby complementing the selectivity for the R isomer observed using the two-step nitrosobenzene method. Use of α-methylproline and α-methylproline tetrazole significantly increases the enantioselectivity observed for the α-oxidation of aldehydes compared to analogous unsubstituted organocatalysts.

Kinetics of oxidation of pantothenic acid by chloramine-T in perchloric acid and in alkaline medium catalyzed by OsO4: A mechanistic approach

Kinetics of oxidation of pantothenic acid (PA) by sodium N-chloro-p-toluenesulfonamide or chloramine-T (CAT) in the presence of HClO 4 and NaOH (catalyzed by OsO4) has been investigated at 313 K. The stoichiometry and oxidation products are same in both media; however, their kinetic patterns were found to be different. In acid medium, the rate shows first-order dependence on |CAT|o, fractional-order dependence on |PA|o, and inverse fractional-order on |H+|. In alkaline medium, the rate shows first-order dependence each on |CAT| o and |PA|o and fractional-order dependence on each of |OH-| and |OsO4|. Effects of added p-toluenesulfonamide and halide ions, varying ionic strength, and dielectric constant of medium as well as solvent isotope on the rate of reaction have been investigated. Activation parameters were evaluated, and the reaction constants involved in the mechanisms have been computed. The proposed mechanisms and the derived rate laws are consistent with the observed kinetics.

Synthesis of Enantiomerically Pure α-Hydroxyaldehydes from the Corresponding α-Hydroxycarboxylic acids: Novel Substrates for Escherichia coli Transketolase

Enantiomerically pure (R)-α-hydroxyaldehydes (>95percent ee) are prepared from the corresponding α-hydroxyesters by silyl protection, reduction with diisobutylaluminium hydride, and finally deprotection under acidic conditions; subsequent coupling of these aldehydes with lithium hydroxypyruvate, catalysed by Escherichia coli transketolase, leads to novel optically pure triols.