6776-45-0Relevant academic research and scientific papers
A direct approach to α-trifluoromethylamines
Gagosz, Fabien,Zard, Samir Z.
, p. 2655 - 2657 (2003)
(Matrix presented) S-[1-(N-Acetylamino)-2,2,2-trifluoroethyl]-O-ethyl dithiocarbonate (6), a readily available xanthate, adds efficiently to various functionalized olefins to give the corresponding adducts 8 via a radical chain reaction initiated by a small amount of lauroyl peroxide.
One-Pot Three-Component Synthesis of Vicinal Diamines via In Situ Aminal Formation and Carboamination
Orcel, Ugo,Waser, Jerome
supporting information, p. 12881 - 12885 (2016/10/04)
A synthesis of vicinal diamines via in situ aminal formation and carboamination of allyl amines is reported. Employing highly electron-poor trifluoromethyl aldimines in their stable hemiaminal form was key to enable both a fast and complete aminal formation as well as the palladium-catalyzed carboamination step. The conditions developed allow the introduction of a wide variety of alkynyl, vinyl, aryl, and hetereoaryl groups with complete regioselectivity and high diastereoselectivity. The reaction exhibits a high functional-group tolerance. Importantly, either nitrogen atom of the imidazolidine products can be selectively deprotected, while removal of the aminal tether can be achieved in a single step under mild conditions to reveal the free diamine. We expect that this work will promote the further use of mixed aminal tethers in organic synthesis.
Novel compounds comprising a thiocarbonyl-sulfanyl group, which can be used for the radical synthesis of-alpha-perfluoroalkylamines
-
Page/Page column 12-13, (2008/06/13)
The invention relates to compounds having the general formula (I), the method of preparation thereof and the use thereof in organic radical synthesis. The invention also relates to compounds having the formula (II), the method of preparation thereof and a
N-Acyl-1-chloro-2,2,2-trifluoroethylamine as a 2,2,2-Trifluoroethylamine-Building Block
Tanaka, Kiyoshi,Ishiguro, Yoshiharu,Mitsuhashi, Keiryo
, p. 661 - 663 (2007/10/02)
The reactions of N-benzoyl- and N-acetyl-1-chloro-2,2,2-trifluoroethylamines with various carbonnucleophiles gave the corresponding 1-substituted N-acyl-2,2,2-trifluoroethylamines in good yields and the efficient reactivity was applied on the synthesis of
