677717-37-2Relevant academic research and scientific papers
Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors
Nakamura, Toshio,Kakinuma, Hiroyuki,Umemiya, Hiroki,Amada, Hideaki,Miyata, Noriyuki,Taniguchi, Kazuo,Bando, Kagumi,Sato, Masakazu
, p. 333 - 336 (2004)
In a previous paper, we reported that an imidazole derivative 1 exhibited a potent inhibitory activity of 20-HETE synthase (1; IC50 value of 5.7 nM), but this compound also exhibited little selectivity for cytochrome P450s (CYPs). We examined some derivatives of imidazole 1 which had an amino group on the side chain, and found that a dimethylaminohexyloxy derivative (3g; IC50 value of 8.8 nM) showed potent and selective inhibitory activity.
