677717-53-2Relevant academic research and scientific papers
Palladium-catalyzed decarboxylative cyanation of aromatic carboxylic acids using [13C] and [14C]-KCN
Loreau, Olivier,Georgin, Dominique,Taran, Frédéric,Audisio, Davide
, p. 425 - 428 (2015)
The development of robust and straightforward methods to efficiently label aromatic moieties starting from simple and convenient radio-synthetic sources still represents a considerable challenge. In this report, a new palladium-catalyzed decarboxylative cyanation protocol has been described. This procedure utilizes [14C]-labeled potassium cyanide, one of the simplest and commercially available sources of carbon-14. Under the optimized reaction conditions, a series of [13C] and [14C]-aromatic nitriles were easily prepared (12-74% yield starting from potassium cyanide). The usefulness of this methodology is highlighted by a rare example of a formal two-step [12C]-[14C] carbon isotope exchange. The current synthetic approach may represent a promising alternative to traditional preparations of relevant building blocks such as labeled aromatic nitriles.
A new short synthesis of coumestrol and its application for the synthesis of [6,6a,11a-13C3]coumestrol
Al-Maharik, Nawaf,Botting, Nigel P.
, p. 1637 - 1642 (2007/10/03)
A convenient and simple two-step method for the synthesis of coumestrol has been established, which involves a base catalysed condensation of phenyl acetate with benzoyl chloride, followed by demethylation and subsequent tandem intramolecular cyclisation. This method was then employed for the efficient synthesis of multiply 13C-labelled coumestrol.
