677745-93-6Relevant academic research and scientific papers
E-SELECTIN ANTAGONIST COMPOUNDS AND METHODS OF USE
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, (2014/05/24)
Provided herein are E-selectin antagonist therapeutic agents and improvements thereto and compositions comprising these E-selectin antagonists. Methods are also provided for using these E-selectin antagonist therapeutic agents to treat and/or prevent diseases and disorders treatable by inhibiting binding of an E-selectin to an E-selectin ligand. Also provided herein improvements to E-selectin antagonist giycomimetic compounds that improve the oral bioavailability of the giycomimetic compounds.
E-SELECTIN ANTAGONIST COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
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, (2013/07/05)
Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation. These E-selection antagonists have the general formula (Ia) below.
Practical syntheses of enantiopure carbasugars: Carba-β-altrose, carba-β-mannose, carba-β-idose, and carba-β-talose derivatives
Yu, Seok-Ho,Chung, Sung-Kee
, p. 581 - 584 (2007/10/03)
D and L forms of carba-β-altrose 8, carba-β-mannose 10a, carba-β-idose 12, carba-β-talose 14 derivatives were prepared from (±)-3-cyclohexene-1-carboxylic acid 1. Homochiral diol compounds D-5a and L-5a, which were prepared from 1 via enzyme resolution of
