677748-52-6Relevant academic research and scientific papers
Synthesis of substituted quinazolines: Application to the synthesis of verubulin
Lockman, Jeffrey W.,Klimova, Yevgeniya,Anderson, Mark B.,Willardsen, J. Adam
experimental part, p. 1715 - 1723 (2012/04/10)
Through newly adapted methodology, 2-methyl-3H-quinazolin-4-one was activated using a number of methods followed by displacement to afford 4-aminoquinazolines. The most useful of these processes utilize the p-toluenesulfonate ester or I2/PPh3 activation. Using this methodology, the anticancer vascular targeting clinical candidate verubulin (1) was synthesized in a highly efficient manner. Copyright Taylor & Francis Group, LLC.
