677751-36-9Relevant academic research and scientific papers
Fast, facile and convenient synthesis of α, α-bis(substituted- arylidene) cycloalkanones: An improved protocol
Mahdavinia, Gholam Hossein,Mirzazadeh, Maryam
, p. 49 - 54 (2012)
Commercially available potassium hydroxide (KOH), a simple base, was found to be a catalyst for tandem cross-aldol condensation between cyclic ketones and aromatic aldehydes leading to a fast and easy synthesis of α,α-bis (substituted-arylidene) cycloalkanones in the shortest times of all previous methods. The reaction of aryl aldehydes with five and six-membered cyclic ketones afforded excellent yields after few seconds in most cases. The reaction conditions were compatible with various electron withdrawing and electron donating substituents, e.g. Cl, F, NO2, OMe, Me and NMe2.
Design, synthesis, and antiproliferative activity assessment of non-ATP-competitive fibroblast growth factor receptor 1 inhibitors
Ying,Wang, Jia,Xu,Kang,Zhang,Shi,Fan,Wang,Zhou,Wu,Wu,Li,Liang
, p. 2744 - 2751 (2017/03/22)
Fibroblast growth factor receptor 1 (FGFR1) is considered a therapeutic target for multiple cancers, including gastric cancer. FGFR1 inhibitors, being ATP competitors, can prevent the kinase domain and the downstream signaling cascade from phosphorylation
