677752-68-0

Basic information

• Product Name: 1-Piperazinecarboxylic acid, 4-[(4-acetylphenyl)sulfonyl]-, 1,1-dimethylethyl ester
• CAS NO: 677752-68-0
• Molecular Formula: C17H24N2O5S
• Molecular Weight: 368.454
• Mol File: 677752-68-0.mol

Chemical Properties

• CAS DataBase Reference: 1-Piperazinecarboxylic acid, 4-[(4-acetylphenyl)sulfonyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinecarboxylic acid, 4-[(4-acetylphenyl)sulfonyl]-, 1,1-dimethylethyl ester(677752-68-0)
• EPA Substance Registry System: 1-Piperazinecarboxylic acid, 4-[(4-acetylphenyl)sulfonyl]-, 1,1-dimethylethyl ester(677752-68-0)

Safety Data

• Hazardous Substances Data: 677752-68-0(Hazardous Substances Data)

Upstream product

• 1788-10-9 4-Acetylbenzenesulfonyl chloride 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 677752-86-2 4-{4-[2-(4-acetylamino-phenylamino)-pyrimidin-4-yl]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 677752-85-1 4-{4-[2-(4-trifluoromethyl-phenylamino)-pyrimidin-4-yl]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 677753-02-5 4-{4-[2-(4-methanesulfonylamino-phenylamino)-pyrimidin-4-yl]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 677753-05-8 4-{4-[2-(4-sulfamoyl-phenylamino)-pyrimidin-4-yl]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 677752-93-1 4-{4-[2-(3,5-difluoro-phenylamino)-pyrimidin-4-yl]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 677752-98-6 4-{4-[2-(benzothiazol-6-ylamino)-pyrimidin-4-yl]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 677753-03-6 4-{4-[2-(4-methanesulfonyl-phenylamino)-pyrimidin-4-yl]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 677753-00-3 4-{4-[2-(4-carbamoyl-phenylamino)-pyrimidin-4-yl]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 677752-94-2 4-{4-[2-(4-methanesulfinyl-phenylamino)-pyrimidin-4-yl]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 677752-97-5 4-{4-[2-(4-nitro-phenylamino)-pyrimidin-4-yl]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 677752-99-7 4-{4-[2-(4-acetyl-phenylamino)-pyrimidin-4-yl]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 677752-96-4 4-{4-[2-(3-cyano-phenylamino)-pyrimidin-4-yl]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 677753-01-4 4-{4-[2-(4-cyano-phenylamino)-pyrimidin-4-yl]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 677752-89-5 4-{4-[2-(4-methoxy-phenylamino)-pyrimidin-4-yl]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

A novel series of potent and selective IKK2 inhibitors

A novel series of aminopyrimidine IKK2 inhibitors have been developed which show excellent in vitro inhibition of this enzyme and good selectivity over the IKK1 isoform. The relative potency and selectivity of these compounds has been rationalized using QSAR and structure-based modelling.