678166-23-9

Upstream product

• 773-64-8 2-mesitylenesulphonyl chloride 
• 112245-13-3 (S)-tert-leucinol 

Downstream Products

• 1032477-17-0 2,2'-diacetoxy-5,5'-di-tert-butyl-3,3'-bis[(2S,4S)-4-tert-butyl-3-(2,4,6-trimethylbenzenesulfonyl)-1,3-oxazolidinyl]biphenyl 
• 1032477-27-2 2,2'-diacetoxy-3,3'-bis[(2S,4S)-4-tert-butyl-3-(2,4,6-trimethylbenzenesulfonyl)-1,3-oxazolidinyl]-biphenyl 
• 1032477-51-2 2-acetoxy-5,5'-di-tert-butyl-3-[(2S,4S)-4-tert-butyl-3-(2,4,6-trimethylbenzenesulfonyl)-1,3-oxazolidinyl]-2'-hydroxy-biphenyl-3'-carbaldehyde 
• 678166-35-3 (4R,2E)-2,5,5-trimethyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]hex-2-en-1-ol 
• 678166-29-5 methyl (4R,2E)-2,5,5-trimethyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]hex-2-enoate 
• 221278-71-3 (4R,2E)-2,5,5-trimethyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]-O-methylsulfonylhex-2-en-1-ol 
• 221278-61-1 (4R,2E)-O-methoxycarbonyl-2,5,5-trimethyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]hex-2-en-1-ol 
• 148838-44-2 N-((S)-1-Formyl-2,2-dimethyl-propyl)-2,4,6-trimethyl-benzenesulfonamide 

Relevant academic research and scientific papers

Asymmetric Strecker reaction of N-benzhydrylimines utilising new tropos biphenyldiol-based ligands

The synthesis of a library of N-arenesulfonyl-1,3-oxazolidinyl-substituted biphenyldiols is presented. A set of two central intermediates together with easily accessible N-arenesulfonylamino alcohols furnish a broad variety of 1,3-oxazolidines. These are applied as chiral tropos ligands in a titanium-mediated Strecker-type reaction of N-benzhydrylimines. A correlation between the ee values in the product and the diastereomeric ratio concerning the chiral axis of the ligand is made. Those substituents in the ligand which proved to lead to a higher preference for one diastereomeric conformer of the chiral axis in related compounds now provide the most selective ligands. Two privileged ligands are identified that afford superior results in 8 of 13 screenings. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

Stereodivergent synthesis of chiral 2-alkenylaziridines: Palladium(0)-catalyzed 2,3-cis-selective aziridination and base-mediated 2,3-trans-selective aziridination

Whereas treatment of the allylic mesylates of N-protected 2-alkyl-4-amino-(E)-2-alken-1-ols with sodium hydride in DMF yields exclusively the corresponding thermodynamically less stable 2,3-trans-2-alkenyl-3- alkylaziridines, exposure of the methyl carbon