67822-75-7Relevant articles and documents
Synthesis and anti-inflammatory activity of sulfonamides and carboxylates incorporating trimellitimides: Dual cyclooxygenase/carbonic anhydrase inhibitory actions
Abdel-Aziz, Alaa A.-M.,Angeli, Andrea,El-Azab, Adel S.,Hammouda, Mohammed E.A.,El-Sherbeny, Magda A.,Supuran, Claudiu T.
, p. 260 - 268 (2018/12/05)
Trimellitimides 6–21 were prepared and investigated in vivo for anti-inflammatory and ulcerogenic effects and in vitro for cytotoxicity. They were subjected to in vitro cyclooxygenase (COX-1/2) and carbonic anhydrase inhibition protocols. Compounds 6–11 a
An expedient method to the synthesis of N-substituted 1H-isoindole-1,3(2H)- diones
Nikpour, Farzad,Mogaddam, Baran Mohammadi
experimental part, p. 2289 - 2292 (2011/04/17)
The synthesis of N-substituted 1H-isoindole-1,3-(2H)-diones is described from the reaction of cyclic anhydrides with Schiff bases as suitable replacing substrates instead of the corresponding amines. The Japan Institute of Heterocyclic Chemistry.
Design and synthesis of phthalimide-type histone deacetylase inhibitors
Shinji, Chihiro,Nakamura, Takanori,Maeda, Satoko,Yoshida, Minoru,Hashimoto, Yuichi,Miyachi, Hiroyuki
, p. 4427 - 4431 (2007/10/03)
Several hydroxamic acid derivatives with a substituted phthalimide group as a linker and/or cap structure, prepared during structural development studies based on thalidomide, were found to have histone deacetylase (HDAC)-inhibitory activity. Structure-activity relationship studies indicated that nature of the substituent introduced at the phthalimide nitrogen atom, introduction of a hydroxamic acid structure, and distance between the N-hydroxyl group and the cap structure are important for HDAC-inhibitory activity.
