1025907-99-6

Upstream product

• 552-30-7 trimellitic Anhydride 
• 863990-92-5 2-(allyloxy)-1,3-dioxoisoindoline-5-carboxylic acid 
• 100-46-9 benzylamine 

Downstream Products

• 67822-79-1 2-benzylisoindolin-1,3-dione-5-carboxylic acid chloride 
• 1027511-63-2 2-Benzyl-5-ethyl-isoindole-1,3-dione 
• 1026257-68-0 2-benzyl-5-acetylisoindolin-1,3-dione 
• 159718-64-6 2-benzyl-5-pentyl-isoindolin-1,3-dione 
• 159718-63-5 2-benzyl-5-pentanoylisoindolin-1,3-dione 
• 67822-75-7 N-benzyl-1,3-dioxoisoindoline-5-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of isotopically-labelled nitroxyl radicals for use as spin probes

The synthesis of [15N]-1,1,3,3-tetrakis(trideuteriomethyl)isoindolin-2-yloxyl and of some 5-alkyl derivatives have been achieved by standard synthetic routes. The presence of deuterium improves the sharpness of the signals, and this, together with the incorporation of nitrogen-15, enhances the application of such compounds as spin probes; allyl substituents at C-5 improve the lipophilicity.

A new supported reagent for the parallel synthesis of primary and secondary O-alkyl hydroxylamines through a base-catalyzed Mitsunobu reaction

The growing field of applications of O-alkyl hydroxylamines in medicinal chemistry and chemical biology has motivated the search for a parallel synthesis. A solid-phase approach based on the alkylation by alcohols of a new supported N-hydroxyphthalimide reagent using a Mitsunobu reaction followed by methylaminolysis has been optimized. This study points out the importance of the linker and a specific base effect for the Mitsunobu reaction. A large variety of alcohols can be used to give with moderate to high yields diverse O-alkyl hydroxylamines in high purity.