67829-50-9Relevant academic research and scientific papers
A Method for Identifying and Developing Functional Group Tolerant Catalytic Reactions: Application to the Buchwald-Hartwig Amination
Richardson, Jeffery,Ruble, J. Craig,Love, Elizabeth A.,Berritt, Simon
, p. 3741 - 3750 (2017)
Transition-metal catalysis has revolutionized organic synthesis, but difficulties can often be encountered when applied to highly functionalized molecules, such as pharmaceuticals and their precursors. This results in discovery collections that are enrich
Efficient construction of C=N double bonds via acceptorless dehydrogenative coupling
Sun, Xiang,Hu, Yu,Nie, Shao-Zhen,Yan, Yun-Yun,Zhang, Xue-Jing,Yan, Ming
supporting information, p. 2179 - 2184 (2013/10/01)
The efficient construction of C=N double bonds has been achieved by the Ir-catalyzed intramolecular acceptorless dehydrogenative cross-coupling of tertiary amines and amides. An iridium/2-hydroxypyridine complex was identified as the highly efficient catalyst. A number of quinazolinone derivatives was prepared in excellent yields. An iridium-mediated C-H activation mechanism is proposed. This finding provides an unprecedented strategy for the direct imidation of sp3 C-H bonds.
Rh[III]-catalyzed direct C-H amination using N -chloroamines at room temperature
Grohmann, Christoph,Wang, Honggen,Glorius, Frank
, p. 656 - 659 (2012/03/08)
An efficient Rh(III)-catalyzed direct C-H amination of N-pivaloyloxy benzamides with N-chloroamines proceeding at room temperature was achieved. The versatile directing group allows for selective mono- and diamination and can be readily converted to give valuable benzamide or aminoaniline derivatives. Mechanistic studies have been carried out to elucidate the reaction pathway.
Substituted benzoylurea compounds or their salts, processes for their production and antitumour compositions containing them
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, (2008/06/13)
A substituted benzoylurea compound of the formula (I): STR1 wherein R1 is a hydrogen atom, a halogen atom or a nitro group, each of R2 and R3 is a hydrogen atom, an alkyl group, --COR6 (wherein R6 is an alkyl group or an alkoxy group) or --SO2 R6 (wherein R6 is as defined above), or R2 and R3 may form together with the adjacent nitrogen atom a heterocyclic ring, R4 is a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted alkylthio group or a nitro group, and R5 is a halogen atom, a nitro group or a substituted or unsubstituted alkyl group, or its salt.
