67836-48-0

Usage

Molecular Structure

Consists of a benzene ring with an attached brominobenzoylamino group, a carboxylic acid, and a methyl ester group.

Functional Groups

Contains an amide group (-CONH2), a carboxylic acid (-COOH), and a methyl ester (-COOCH3) group.

Bromine Content

Has a bromine atom attached to the benzene ring, which may contribute to its medicinal properties.

Molecular Weight

333.11 g/mol.

Physical State

Solid.

Solubility

Soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO).

Potential Medicinal Uses

May have applications in the treatment of various medical conditions, although further research is needed to fully understand its properties and potential uses.

Laboratory and Pharmaceutical Applications

Frequently used in laboratory research and pharmaceutical development due to its potential medicinal properties.

InChI:InChI=1/C15H12BrNO3/c1-20-15(19)12-7-2-3-8-13(12)17-14(18)10-5-4-6-11(16)9-10/h2-9H,1H3,(H,17,18)

Upstream product

• 1711-09-7 3-bromobenzoyl chloride 
• 134-20-3 2-carbomethoxyaniline 
• 585-76-2 m-bromobenzoic acid 

Downstream Products

• 106782-83-6 2-(3-bromo-phenyl)-benzo[d][1,3]thiazine-4-thione 
• 106882-42-2 2-(3-bromo-phenyl)-benzo[d][1,3]thiazin-4-one 
• 53463-67-5 2-(3-Bromo-phenyl)-4H-3,1-benzoxazin-4-one 

Relevant academic research and scientific papers

Asymmetric Synthesis of N-N Axially Chiral Compounds by Phase-Transfer-Catalyzed Alkylations

N-N axially chiral skeletons are significant structural motifs in natural products, pharmaceuticals, and functional materials. Herein we disclose a method for the asymmetric synthesis of N-N axially chiral compounds by phase-transfer catalysis. A wide range of N-N axially chiral quinazolinone derivatives were prepared in high yields with excellent stereoselectivities. Furthermore, the synthetic utility of the protocol was proved by large-scale reaction and transformation of the product. Density functional theory calculations provide insight into the mechanism.

The evaluation and structure-activity relationships of 2-benzoylaminobenzoic esters and their analogues as anti-inflammatory and anti-platelet aggregation agents

Forty-seven 2-benzoylaminobenzoic esters were synthesized and evaluated in anti-platelet aggregation, inhibition of superoxide anion generation, and inhibition of neutrophil elastase release assays. Most 2-benzoylamino-4-chlorobenzoic acid derivatives showed selective inhibitory effects on arachidonic acid (AA)-induced platelet aggregation. Among them, compounds 6b and 7b exhibited more potent inhibitory effects (ca. 200-fold) than aspirin. Additionally, compounds 1a and 5a showed strong inhibitory effects on neutrophil superoxide generation with IC50 values of 0.65 and 0.17 μM, respectively. However, compounds 6d and 6e exhibited dual inhibitory effects on platelet aggregation and neutrophil elastase (NE) release; therefore, these two compounds may be new leads for development as anti-inflammatory and anti-platelet aggregatory agents.

Structure-based design, synthesis, and study of potent inhibitors of β-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents

Fatty acid biosynthesis is essential for bacterial survival. Components of this biosynthetic pathway have been identified as attractive targets for the development of new antibacterial agents. FabH, β-ketoacyl-ACP synthase III, is a particularly attractiv